Natriuretic peptides, which are activated in heart failure, play an important cardioprotective
role. The most notable of the cardioprotective natriuretic peptides are atrial natriuretic …

Neprilysin (NEP) is an integral membrane-bound metallopeptidase with a wide spectrum of
substrates and physiological functions. It plays an important role in proteolytic processes in …

The definition of nocturnal hypertension is night-time BP≥ 120/70 mm Hg (> 110/65 mm Hg
by the new 2017ACC/AHA guidelines; Table 1). Clinic and morning home BP of< 130/80 …

Hypertension is an important public health issue because of its association with a number of
significant diseases and adverse outcomes. However, there are important ethnic differences …

This phase III study assessed the efficacy and safety of sacubitril/valsartan compared with
those of olmesartan in Japanese patients with essential hypertension. Patients (n= 1161 …

Heart failure (HF) is a common condition with an increasing prevalence. Despite a variety of
evidence-based treatments for patients with HF with reduced ejection fraction, morbidity and …

Hypertension is a significant and increasing global health issue. It is a leading cause of
cardiovascular disease and premature death worldwide due to its effects on end organs …

Despite the availability of multiple antihypertensive drugs targeting the different pathways
implicated in its pathophysiology, hypertension remains poorly controlled worldwide, and its …

ESSENTIAL MANUAL OF 24-HOUR BLOOD PRESSURE MANAGEMENT Hypertension is
one of the greatest threats to human health. The World Health Organization (WHO) …

Angiotensin receptor–neprilysin inhibitors have multiple beneficial effects on the
cardiovascular system. The angiotensin receptor–neprilysin inhibitor sacubitril/valsartan has …