Reactive oxygen species (ROS) play a critical role in defining the functional competence of
human spermatozoa. When generated in moderate amounts, ROS promote sperm …

In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

Abstract Background Between 30% and 80% of patients with male infertility produce
excessive reactive oxygen species (ROS) in their ejaculate even though the cause of male …

Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …

Spermatogenesis is a complex process in the testis and is a cornerstone of male infertility.
The abundance of unsaturated fatty acid and high cell division rate make male germs cells …

In modern post-transition societies, we are reproducing later and living longer. While the
impact of age on female reproductive function has been well studied, much less is known …

The spermatozoon is a highly specialized cell, whose main function is the transport of the
intact male genetic material into the oocyte. During its formation and transit throughout male …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

Bisphenol A (BPA) is an environmental endocrine disruptor. Recent studies have shown an
association between decreased spermatogenesis and gut microbiota alteration. However …

Both physiological and pathological aging processes induce brain alterations especially
affecting the speed of processing, working memory, conceptual reasoning and executive …