Cystic fibrosis (CF) is a heritable, multiorgan disease that impacts all tissues that normally
express cystic fibrosis transmembrane conductance regulator (CFTR) protein. While the …

Highlights•Pseudomonas aeruginosa in CF airways: paradigm of bacterial microevolution.•
Evolution within CF host triggers conversions of genotype and phenotype.•Severity of lung …

The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lungs of
patients with cystic fibrosis (CF). During infection the bacteria evolve and adapt to the lung …

Worldwide, Pseudomonas aeruginosa remains a leading nosocomial pathogen that is
difficult to treat and constitutes a challenging menace to healthcare systems. P. aeruginosa …

Pseudomonas aeruginosa and Staphylococcus aureus are among the most frequently
isolated bacterial species from polymicrobial infections of patients with cystic fibrosis and …

Pseudomonas aeruginosa is a versatile pathogen that resists environmental stress, such as
suboptimal pH. As a result of exposure to environmental stress, P. aeruginosa shows an …

Introduction With the increasingly serious problem of antiviral drug resistance, drug
repurposing offers a time-efficient and cost-effective way to find potential therapeutic agents …

The human pathogens Pseudomonas aeruginosa and Staphylococcus aureus are
frequently co-isolated from chronic wounds or cystic fibrosis patient airways. Clinical studies …

Objective Lung cystic fibrosis (CF) is characterized by chronic infections and
hyperinflammatory response of neutrophils and macrophages. P. aeruginosa (PA) and S …

Pseudomonas aeruginosa is a pathogen frequently encountered in healthcare-associated
infections and immunocompromised patients. In bacteremia, this pathogen is associated …