Kidney fibrosis is a common histological manifestation of functional decline in the kidney.
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …

Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …

Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis of chronic
kidney diseases. As Klotho is a large transmembrane protein, it is challenging to harness it …

Diabetic Nephropathy (DN) is believed to be a major microvascular complication of
diabetes. The hallmark of DN includes deposition of Extracellular Matrix (ECM) proteins …

Chronic kidney disease (CKD) is an important health concern that is expected to be the fifth
most widespread cause of death worldwide by 2040. The presence of chronic inflammation …

Acute kidney injury (AKI) is a major kidney disease featured by a rapid decline of renal
function. Pathologically, AKI is characterized by tubular epithelial cell injury and death …

The cholestatic liver injury could occur in response to a variety of diseases or xenobiotics.
Although cholestasis primarily affects liver function, it has been well-known that other organs …

Peritendinous tissue fibrosis which leads to poor tendon function is a worldwide clinical
problem; however, its mechanism remains unclear. Transcription factor RelA/p65, an …

Inflammation and fibrosis are implicated in the pathogenesis of hypertensive kidney
damage. We previously demonstrated that a nonspecific histone deacetylase (HDAC) …

Kidney is a vital organ with high energy demands to actively maintain plasma
hemodynamics, electrolytes and water homeostasis. Among the nephron segments, the …