Neuropathic pain is a chronic condition that is difficult to be treated. Current therapies
available are either ineffective or non-specific thus requiring newer treatment approaches. In …

Objective. We investigated potential analgesics for chemotherapy-evoked neuropathic pain
using rats treated with paclitaxel. Design. Drugs were tested in a repeated dosing paradigm …

We compared the preclinical analgesic activity of three marketed drugs with different
pharmacological properties, pregabalin, tramadol and duloxetine, described as effective …

Methods Male Sprague–Dawley rats were randomly divided into three groups: the sham
group, exposure of anterior parts of the heart was carried out without ligation of the coronary …

Berberine is an isoquinoline alkaloid naturally produced by several types of plants.
Berberine has extensive pharmacological effects, such as anti-diabetic, anti-inflammatory …

In addition to well-known analgesic action of tramadol, its potential antinflammatory effects
have not been thoroughly evaluated. On the other hand, effectiveness of antioxidants is also …

ABSTRACT Preclinical Research The presence of pain as part of the cancer process is
variable. Glioblastoma multiform (GBM) can produce bone metastasis, a condition that …

Purpose: Anticonvulsants, antidepressants, local anesthetics, sodium channel blockers,
drugs such as narcotic analgesics but also on alternative therapies has been extensively …

Amaç: Yaşam kalitesini düşüren nöropatik ağrının tedavisinde antikonvülsanlar,
antidepresanlar, lokal anestezikler, sodyum kanal blokörleri, narkotik analjezikler gibi ilaçlar …

The aim of the present study was to evaluate putative antinociceptive effects of simvastatin
and contribution of nitric oxide to experimental neuropathic pain model in rats. 48 Male …