[HTML][HTML] Pathophysiology of obesity and its associated diseases

X Jin, T Qiu, L Li, R Yu, X Chen, C Li, CG Proud… - … Pharmaceutica Sinica B, 2023 - Elsevier
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …

Interplay of skeletal muscle and adipose tissue: sarcopenic obesity

MJ Park, KM Choi - Metabolism, 2023 - Elsevier
Sarcopenic obesity is becoming a global health concern, owing to the rising older
population, causing cardiometabolic morbidity and mortality. Loss of muscle exceeding …

TyG index is positively associated with risk of CHD and coronary atherosclerosis severity among NAFLD patients

J Zhao, H Fan, T Wang, B Yu, S Mao, X Wang… - Cardiovascular …, 2022 - Springer
Background Insulin resistance (IR), endothelial dysfunction, inflammation, glucose and lipid
metabolism disorders, and thrombosis are believed involved in coronary heart disease …

The role of insulin resistance in fueling NAFLD pathogenesis: from molecular mechanisms to clinical implications

R Palma, A Pronio, M Romeo, F Scognamiglio… - Journal of Clinical …, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) represents a predominant hepatopathy that is
rapidly becoming the most common cause of hepatocellular carcinoma worldwide. The …

Adipose-derived mesenchymal stem cells therapy as a new treatment option for diabetes mellitus

A Mikłosz, A Chabowski - The Journal of Clinical Endocrinology …, 2023 - academic.oup.com
The worldwide increase in the prevalence of diabetes mellitus has raised the demand for
new therapeutic strategies targeting diabetic symptoms and its chronic complications …

Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches

PF Ding, HS Zhang, J Wang, YY Gao, JN Mao… - Frontiers in …, 2022 - frontiersin.org
The pathological condition of insulin resistance prevents the neuroprotective effects of
insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk …

Roles of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome

H Koike, M Harada, A Kusamoto, Z Xu… - Frontiers in …, 2023 - frontiersin.org
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among
reproductive-age women, affecting up to 15% of women in this group, and the most common …

Acute exposure to realistic concentrations of Bisphenol-A trigger health damage in fish: Blood parameters, gene expression, oxidative stress

GA Elizalde-Velázquez, LM Gómez-Oliván… - Aquatic Toxicology, 2023 - Elsevier
Despite much information regarding BPA toxicity in fish and other aquatic organisms, data is
still misleading as most studies have utilized concentrations several orders of magnitude …

White adipose tissue dysfunction: pathophysiology and emergent measurements

N Santillana, C Astudillo-Guerrero, A D'Espessailles… - Nutrients, 2023 - mdpi.com
White adipose tissue (AT) dysfunction plays an important role in the development of
cardiometabolic alterations associated with obesity. AT dysfunction is characterized by the …

The metabolic score for insulin resistance (METS-IR) predicts cardiovascular disease and its subtypes in patients with hypertension and obstructive sleep apnea

W Yang, X Cai, J Hu, W Wen, H Mulalibieke… - Clinical …, 2023 - Taylor & Francis
Objective We aimed to evaluate the METS-IR (metabolic score for insulin resistance) index
for the prediction of incident cardiovascular disease (CVD) and its subtypes (coronary artery …