Sodium–Glucose Cotransporter Inhibitors: Cellular Mechanisms Involved in the Lipid Metabolism and the Treatment of Chronic Kidney Disease Associated with …

F Cortés-Camacho, OR Zambrano-Vásquez… - Antioxidants, 2024 - mdpi.com
Metabolic syndrome (MetS) is a multifactorial condition that significantly increases the risk of
cardiovascular disease and chronic kidney disease (CKD). Recent studies have …

Glucose homeostasis, diabetes mellitus, and gender-affirming treatment

C Milionis, I Ilias, E Venaki, E Koukkou - Biomedicines, 2023 - mdpi.com
The transgender (trans) population includes individuals with gender identities more fittingly
aligned with the opposite sex or with an alternative that transcends the classical dipole of …

Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption

K Unno, K Taguchi, Y Takagi, T Hase… - International Journal of …, 2023 - mdpi.com
The sodium–glucose cotransporter 2 (SGLT2) mainly carries out glucose reabsorption in the
kidney. Familial renal glycosuria, which is a mutation of SGLT2, is known to excrete glucose …

Potential molecular targets of oleanolic acid in insulin resistance and underlying oxidative stress: a systematic review

A Fernandez-Aparicio, M Correa-Rodriguez… - Antioxidants, 2022 - mdpi.com
Oleanolic acid (OA) is a natural triterpene widely found in olive leaves that possesses
antioxidant, anti-inflammatory, and insulin-sensitizing properties, among others. These OA …

Pathophysiological effects of contemporary lifestyle on evolutionary-conserved survival mechanisms in polycystic ovary syndrome

J Parker - Life, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is increasingly being characterized as an evolutionary
mismatch disorder that presents with a complex mixture of metabolic and endocrine …

Effects of Consuming Beverages Sweetened with Fructose, Glucose, High-Fructose Corn Syrup, Sucrose, or Aspartame on OGTT-Derived Indices of Insulin Sensitivity …

B Hieronimus, V Medici, V Lee, MV Nunez, DM Sigala… - Nutrients, 2024 - mdpi.com
(1) Background: Clinical results on the effects of excess sugar consumption on insulin
sensitivity are conflicting, possibly due to differences in sugar type and the insulin sensitivity …

The Antiobesity Effects and Potential Mechanisms of Theaflavins

Y Fang, J Wang, Y Cao, W Liu, L Duan… - Journal of Medicinal …, 2024 - liebertpub.com
Theaflavins are the characteristic polyphenols in black tea which can be enzymatically
synthesized. In this review, the effects and molecular mechanisms of theaflavins on obesity …

Outcomes With Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Baseline Insulin Resistance

T Ebert, SD Anker, LM Ruilope, P Fioretto… - Diabetes …, 2024 - Am Diabetes Assoc
OBJECTIVE To explore whether insulin resistance, assessed by estimated glucose disposal
rate (eGDR), is associated with cardiorenal risk and whether it modifies finerenone efficacy …

[HTML][HTML] Molecular mechanism and therapeutic strategy of bile acids in Alzheimer's disease from the emerging perspective of the microbiota–gut–brain axis

M Wu, Y Cheng, R Zhang, W Han, H Jiang, C Bi… - Biomedicine & …, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid-β outside neurons and Tau protein inside neurons. Various …

Advancing the understanding of diabetic encephalopathy through unravelling pathogenesis and exploring future treatment perspectives

A Nagayach, R Bhaskar, S Ghosh, KK Singh… - Ageing Research …, 2024 - Elsevier
Diabetic encephalopathy (DE), a significant micro-complication of diabetes, manifests as
neurochemical, structural, behavioral, and cognitive alterations. This condition is especially …