Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus
Diabetes mellitus is characterized by the failure of insulin-secreting pancreatic β-cells (or β-
cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for …
cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for …
[HTML][HTML] Inflammatory responses and inflammation-associated diseases in organs
L Chen, H Deng, H Cui, J Fang, Z Zuo, J Deng, Y Li… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Inflammation is a biological response of the immune system that can be triggered by a
variety of factors, including pathogens, damaged cells and toxic compounds. These factors …
variety of factors, including pathogens, damaged cells and toxic compounds. These factors …
Type 2 diabetes as an inflammatory disease
MY Donath, SE Shoelson - Nature reviews immunology, 2011 - nature.com
Components of the immune system are altered in obesity and type 2 diabetes (T2D), with the
most apparent changes occurring in adipose tissue, the liver, pancreatic islets, the …
most apparent changes occurring in adipose tissue, the liver, pancreatic islets, the …
Diabetes mellitus and inflammation
E Lontchi-Yimagou, E Sobngwi, TE Matsha… - Current diabetes …, 2013 - Springer
Type 2 diabetes mellitus (T2DM) is increasingly common worldwide. Related complications
account for increased morbidity and mortality, and enormous healthcare spending …
account for increased morbidity and mortality, and enormous healthcare spending …
[PDF][PDF] Metabolic inflammation-associated IL-17A causes non-alcoholic steatohepatitis and hepatocellular carcinoma
Obesity increases hepatocellular carcinoma (HCC) risks via unknown mediators. We report
that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to …
that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to …
[PDF][PDF] Expansion of islet-resident macrophages leads to inflammation affecting β cell proliferation and function in obesity
The nature of obesity-associated islet inflammation and its impact on β cell abnormalities
remains poorly defined. Here, we explore immune cell components of islet inflammation and …
remains poorly defined. Here, we explore immune cell components of islet inflammation and …
Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β‐Cell Dysfunction
The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …
Inflammatory mechanisms in obesity
MF Gregor, GS Hotamisligil - Annual review of immunology, 2011 - annualreviews.org
The modern rise in obesity and its strong association with insulin resistance and type 2
diabetes have elicited interest in the underlying mechanisms of these pathologies. The …
diabetes have elicited interest in the underlying mechanisms of these pathologies. The …
Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is characterized by progressive β‐cell dysfunctioning and
insulin resistance. This article reviews recent literature with special focus on inflammatory …
insulin resistance. This article reviews recent literature with special focus on inflammatory …
[HTML][HTML] Defining and characterizing the progression of type 2 diabetes
VA Fonseca - Diabetes care, 2009 - ncbi.nlm.nih.gov
Type 2 diabetes is a progressive dis-ease in which the risks of myocardial infarction, stroke,
microvascular events, and mortality are all strongly associated with hyperglycemia (1). The …
microvascular events, and mortality are all strongly associated with hyperglycemia (1). The …