[HTML][HTML] Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
N Albinger, J Hartmann, E Ullrich - Gene therapy, 2021 - nature.com
Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful
immunotherapeutic tools for combating hematological diseases confronted with pressing …
immunotherapeutic tools for combating hematological diseases confronted with pressing …
[HTML][HTML] Natural killer cells: development, maturation, and clinical utilization
AM Abel, C Yang, MS Thakar… - Frontiers in …, 2018 - frontiersin.org
Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …
[HTML][HTML] Natural killer cells in clinical development as non-engineered, engineered, and combination therapies
N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …
[HTML][HTML] Cancer immunotherapy based on natural killer cells: current progress and new opportunities
W Hu, G Wang, D Huang, M Sui, Y Xu - Frontiers in immunology, 2019 - frontiersin.org
Cancer immunotherapy has been firmly established as a new milestone for cancer therapy,
with the development of multiple immune cells as therapeutic tools. Natural killer (NK) cells …
with the development of multiple immune cells as therapeutic tools. Natural killer (NK) cells …
[PDF][PDF] Human iPSC-derived natural killer cells engineered with chimeric antigen receptors enhance anti-tumor activity
Chimeric antigen receptors (CARs) significantly enhance the anti-tumor activity of immune
effector cells. Although most studies have evaluated CAR expression in T cells, here we …
effector cells. Although most studies have evaluated CAR expression in T cells, here we …
[HTML][HTML] Current perspectives on “off-the-shelf” allogeneic NK and CAR-NK cell therapies
EL Heipertz, ER Zynda, TE Stav-Noraas… - Frontiers in …, 2021 - frontiersin.org
Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily
located in peripheral circulation and lymphoid tissues. They kill virally infected and …
located in peripheral circulation and lymphoid tissues. They kill virally infected and …
[HTML][HTML] Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy
A Yilmaz, H Cui, MA Caligiuri, J Yu - Journal of hematology & oncology, 2020 - Springer
Natural killer (NK) cells are a critical component of the innate immune system. Chimeric
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …
[HTML][HTML] Natural killer cells: a promising immunotherapy for cancer
J Chu, F Gao, M Yan, S Zhao, Z Yan, B Shi… - Journal of translational …, 2022 - Springer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …
recently gained attention as an important type of innate immune regulatory cell. NK cells can …
[HTML][HTML] NKG2D-CAR-transduced natural killer cells efficiently target multiple myeloma
A Leivas, A Valeri, L Córdoba, A García-Ortiz… - Blood Cancer …, 2021 - nature.com
CAR-T-cell therapy against MM currently shows promising results, but usually with serious
toxicities. CAR-NK cells may exert less toxicity when redirected against resistant myeloma …
toxicities. CAR-NK cells may exert less toxicity when redirected against resistant myeloma …
Selenium‐containing nanoparticles combine the NK cells mediated immunotherapy with radiotherapy and chemotherapy
S Gao, T Li, Y Guo, C Sun, B Xianyu… - Advanced Materials, 2020 - Wiley Online Library
Considering the limited clinical benefits of individual approaches against malignancy,
natural killer (NK) cell‐mediated immunotherapy is increasingly utilized in combination with …
natural killer (NK) cell‐mediated immunotherapy is increasingly utilized in combination with …