ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology …
Cardiac arrhythmias are a major cause of death and disability. A large number of
experimental cell and animal models have been developed to study arrhythmogenic …
experimental cell and animal models have been developed to study arrhythmogenic …
Regulation of HCN channels by protein interactions
Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels are key regulators
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …
[HTML][HTML] Aging Process and Related Diseases
The aging process is a complex biological phenomenon that results in the gradual decline of
physiological function and an increased risk of age-related diseases. While aging is a …
physiological function and an increased risk of age-related diseases. While aging is a …
Pharmacologic approach to sinoatrial node dysfunction
P Mesirca, VV Fedorov, TJ Hund… - Annual review of …, 2021 - annualreviews.org
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …
ß-tubulin contributes to Tongyang Huoxue decoction-induced protection against hypoxia/reoxygenation-induced injury of sinoatrial node cells through SIRT1 …
X Chang, Y Li, J Liu, Y Wang, X Guan, Q Wu, Y Zhou… - Phytomedicine, 2023 - Elsevier
Abstract Background TYHX-Tongyang Huoxue decoction has been used clinically for nearly
40 years. The ingredients of TYHX are Radix Astragali (Huangqi), Red Ginseng (Hongshen) …
40 years. The ingredients of TYHX are Radix Astragali (Huangqi), Red Ginseng (Hongshen) …
Slowing down as we age: aging of the cardiac pacemaker's neural control
The cardiac pacemaker ignites and coordinates the contraction of the whole heart,
uninterruptedly, throughout our entire life. Pacemaker rate is constantly tuned by the …
uninterruptedly, throughout our entire life. Pacemaker rate is constantly tuned by the …
SGLT2 inhibitors in aging-related cardiovascular disease: A review of potential mechanisms
Y Zhang, Y He, S Liu, L Deng, Y Zuo, K Huang… - American Journal of …, 2023 - Springer
Population aging combined with higher susceptibility to cardiovascular diseases in older
adults is increasing the incidence of conditions such as atherosclerosis, myocardial …
adults is increasing the incidence of conditions such as atherosclerosis, myocardial …
Genetics of sinoatrial node function and heart rate disorders
LE van der Maarel, AV Postma… - Disease models & …, 2023 - journals.biologists.com
The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its
electrical activation and ensuring that the heart's functional cardiac output meets …
electrical activation and ensuring that the heart's functional cardiac output meets …
Physiology of aging
GE Taffet - Geriatric Medicine: A Person Centered Evidence …, 2024 - Springer
With aging, there is an apparent depletion of physiologic reserves that has been termed
homeostenosis. When the reserves are depleted, the older adult is intolerant of further …
homeostenosis. When the reserves are depleted, the older adult is intolerant of further …
Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes
Sinoatrial node myocytes (SAMs) act as cardiac pacemaker cells by firing spontaneous
action potentials (APs) that initiate each heartbeat. The funny current (If) is critical for the …
action potentials (APs) that initiate each heartbeat. The funny current (If) is critical for the …