[HTML][HTML] HDL in atherosclerotic cardiovascular disease: in search of a role
For a long time, high-density lipoprotein cholesterol (HDL-C) has been regarded as a
cardiovascular disease (CVD) protective factor. Recently, several epidemiological studies …
cardiovascular disease (CVD) protective factor. Recently, several epidemiological studies …
[PDF][PDF] HDL in infectious diseases and sepsis
During infection significant alterations in lipid metabolism and lipoprotein composition occur.
Triglyceride and VLDL cholesterol levels increase, while reduced HDL cholesterol (HDL-C) …
Triglyceride and VLDL cholesterol levels increase, while reduced HDL cholesterol (HDL-C) …
PCSK9 deficiency reduces insulin secretion and promotes glucose intolerance: the role of the low-density lipoprotein receptor
Aims PCSK9 loss of function genetic variants are associated with lower low-density
lipoprotein cholesterol but also with higher plasma glucose levels and increased risk of Type …
lipoprotein cholesterol but also with higher plasma glucose levels and increased risk of Type …
High density lipoprotein cholesterol and the risk of all-cause mortality among US veterans
Results Patients with low HDL cholesterol and low eGFR had a higher burden of comorbid
illnesses. Over a median of 9.1 years (interquartile range, 7.7–9.4 years), 26,247 (40.1%) …
illnesses. Over a median of 9.1 years (interquartile range, 7.7–9.4 years), 26,247 (40.1%) …
[HTML][HTML] Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
F Bonacina, D Coe, G Wang, MP Longhi… - Nature …, 2018 - nature.com
Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show
that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell …
that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell …
[PDF][PDF] Obesity-induced metabolic stress leads to biased effector memory CD4+ T cell differentiation via PI3K p110δ-Akt-mediated signals
C Mauro, J Smith, D Cucchi, D Coe, H Fu, F Bonacina… - Cell metabolism, 2017 - cell.com
Low-grade systemic inflammation associated to obesity leads to cardiovascular
complications, caused partly by infiltration of adipose and vascular tissue by effector T cells …
complications, caused partly by infiltration of adipose and vascular tissue by effector T cells …
Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering
Proprotein convertase subtilisin kexin 9 (PCSK9) is a key regulator of low-density lipoprotein
receptor levels and LDL-cholesterol levels. Loss-of-function mutations in PCSK9 gene are …
receptor levels and LDL-cholesterol levels. Loss-of-function mutations in PCSK9 gene are …
Systemic and renal lipids in kidney disease development and progression
P Wahl, GM Ducasa, A Fornoni - American Journal of …, 2016 - journals.physiology.org
Altered lipid metabolism characterizes proteinuria and chronic kidney diseases. While it is
thought that dyslipidemia is a consequence of kidney disease, a large body of clinical and …
thought that dyslipidemia is a consequence of kidney disease, a large body of clinical and …
[HTML][HTML] Low levels of high-density lipoprotein cholesterol increase the risk of incident kidney disease and its progression
Available experimental evidence suggests a role for high-density lipoprotein cholesterol
(HDL-C) in incident chronic kidney disease (CKD) and its progression. However, clinical …
(HDL-C) in incident chronic kidney disease (CKD) and its progression. However, clinical …
Circulating non-coding RNAs in chronic kidney disease and its complications
AJ van Zonneveld, Q Zhao, JI Rotmans… - Nature Reviews …, 2023 - nature.com
Post-transcriptional regulation by non-coding RNAs (ncRNAs) can modulate the expression
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …