Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …

Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and
type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic …

Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on
glucose metabolism, causes functional impairments in several metabolic pathways, both in …

A growing body of evidence highlights the close association between nutrition and human
health. Fat is an essential macronutrient, and vegetable oils, such as palm oil, are widely …

Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and
ATP synthesis but also cause serious stress to various tissues, contributing to the …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive
fatty acid release may worsen adipose tissue inflammation and contributes to insulin …

Solid tumors typically develop hostile microenvironments characterized by irregular
vascularization and poor oxygen (O 2) and nutrient supply. Whereas normal cells modulate …

Mitochondria are critical for respiration in all tissues; however, in liver, these organelles also
accommodate high-capacity anaplerotic/cataplerotic pathways that are essential to …

Fatty liver, oxidative stress, and mitochondrial dysfunction are key pathophysiological
features of insulin resistance and obesity. Butyrate, produced by fermentation in the large …