[HTML][HTML] Sarcopenia–Molecular mechanisms and open questions
P Wiedmer, T Jung, JP Castro, LCD Pomatto… - Ageing research …, 2021 - Elsevier
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …
Palmitic and oleic acid: the yin and yang of fatty acids in type 2 diabetes mellitus
X Palomer, J Pizarro-Delgado, E Barroso… - Trends in Endocrinology …, 2018 - cell.com
Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and
type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic …
type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic …
Insulin resistance, obesity and lipotoxicity
Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on
glucose metabolism, causes functional impairments in several metabolic pathways, both in …
glucose metabolism, causes functional impairments in several metabolic pathways, both in …
[HTML][HTML] Biological and nutritional properties of palm oil and palmitic acid: effects on health
A Mancini, E Imperlini, E Nigro, C Montagnese… - Molecules, 2015 - mdpi.com
A growing body of evidence highlights the close association between nutrition and human
health. Fat is an essential macronutrient, and vegetable oils, such as palm oil, are widely …
health. Fat is an essential macronutrient, and vegetable oils, such as palm oil, are widely …
[HTML][HTML] Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes
Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and
ATP synthesis but also cause serious stress to various tissues, contributing to the …
ATP synthesis but also cause serious stress to various tissues, contributing to the …
[HTML][HTML] Mitochondrial dysfunction and insulin resistance: an update
MK Montgomery, N Turner - Endocrine connections, 2015 - ec.bioscientifica.com
Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …
however, a large variety of association and intervention studies as well as genetic …
The pathogenesis of obesity-associated adipose tissue inflammation
A Engin - Obesity and lipotoxicity, 2017 - Springer
Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive
fatty acid release may worsen adipose tissue inflammation and contributes to insulin …
fatty acid release may worsen adipose tissue inflammation and contributes to insulin …
[HTML][HTML] Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment
D Ackerman, MC Simon - Trends in cell biology, 2014 - cell.com
Solid tumors typically develop hostile microenvironments characterized by irregular
vascularization and poor oxygen (O 2) and nutrient supply. Whereas normal cells modulate …
vascularization and poor oxygen (O 2) and nutrient supply. Whereas normal cells modulate …
[HTML][HTML] Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver
S Satapati, B Kucejova, JAG Duarte… - The Journal of …, 2015 - Am Soc Clin Investig
Mitochondria are critical for respiration in all tissues; however, in liver, these organelles also
accommodate high-capacity anaplerotic/cataplerotic pathways that are essential to …
accommodate high-capacity anaplerotic/cataplerotic pathways that are essential to …
Butyrate regulates liver mitochondrial function, efficiency, and dynamics in insulin-resistant obese mice
MP Mollica, G Mattace Raso, G Cavaliere… - Diabetes, 2017 - Am Diabetes Assoc
Fatty liver, oxidative stress, and mitochondrial dysfunction are key pathophysiological
features of insulin resistance and obesity. Butyrate, produced by fermentation in the large …
features of insulin resistance and obesity. Butyrate, produced by fermentation in the large …