Simple Summary Multiple myeloma (MM) is a still uncurable tumor of mainly elderly patients
originating from the terminally differentiated B cells. Introduction to the treatment of MM …

Proteases are enzymes that hydrolyze peptide bonds in proteins and peptides; thus, they
control virtually all biological processes. Our understanding of protease function has …

The hexosamine biosynthetic pathway (HBP) produces the essential metabolite UDP-
GlcNAc and plays a key role in metabolism, health, and aging. The HBP is controlled by its …

Proteasome inhibitors (PIs) are a fascinating class of small molecules that disrupt protein
homeostasis and are highly efficacious in the blood cancer multiple myeloma. However, PIs …

Small molecule chemical probes are valuable tools for interrogating protein biological
functions and relevance as a therapeutic target. Rigorous validation of chemical probe …

Since multiple myeloma (MM) remains a cureless malignancy of plasma cells to date, it
becomes imperative to develop novel drugs and therapeutic targets for MM. We screened a …

Protein homeostasis is modulated by stress response pathways and its deficiency is a
hallmark of aging. The integrated stress response (ISR) is a conserved stress-signaling …

Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of
clonal plasma cells in the bone marrow (BM). It is known that early genetic mutations in post …

Simple Summary Advances in treatment, especially with novel drugs, have dramatically
improved the survival of multiple myeloma (MM) patients recently. However, frequent …

Proteasome-addicted neoplastic malignancies present a considerable refractory and
relapsed phenotype with patients exhibiting drug resistance and high mortality rates. To …