Three main barrier layers at the interface between blood and tissue protect the central
nervous system (CNS): the endothelium of brain capillaries, and the epithelia of the choroid …

Neurodegenerative and infectious disorders including Alzheimer's and Parkinson's
diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population's …

Formation of cerebral oedema caused by vascular leakage is a major problem in various
injuries of the CNS, such as stroke, head injury and highaltitude illness. A common feature …

Extracellular adenosine has been implicated in adaptation to hypoxia and previous studies
demonstrated a central role in vascular responses. Here, we examined the contribution of …

The endothelial cells (EC) of the microvasculature in the brain form the anatomical basis of
the blood–brain barrier (BBB). In the present study, the effects of agents that modify the …

High-intensity focused ultrasound (HIFU) has been shown to generate lesions that destroy
brain tissue while disrupting the blood-brain barrier (BBB) in the periphery of the lesion. BBB …

Traumatic brain injury is a serious cause of morbidity and mortality worldwide. After
traumatic brain injury, the blood–brain barrier, the protective barrier between the brain and …

Systemic lupus erythematosus is an autoimmune disease in which most patients express
Abs that bind double-stranded DNA. Recent work has shown that a subset of lupus Abs can …

Since the pioneering work dealing with the synthesis and physicochemical aspects of
dendrimers, a predictable and tunable set of compositions for therapeutic, scaffolding and …

We assessed the acute effects of radiation on the rat blood–brain barrier. A cranial window
model and intravital microscopy were used to measure changes in permeability and …