We have investigated the possibility that soluble, blood-borne amyloid beta (Aβ) peptides
can cross a defective blood–brain barrier (BBB) and interact with neurons in the brain …

Cerebral malaria is a major killer in the developing world, but we still know very little about
the causes of this disease. How does Plasmodium falciparum cause such a devastating …

Many diseases share the common feature of vascular leakage, and endothelial barrier
dysfunction is often the underlying cause. The subsequent stages of endothelial barrier …

Basal vascular endothelial permeability is normally kept low in part by the restrictiveness of
interendothelial junctions (IEJs). We investigated the possible role of nitric oxide (NO) in …

Objective: The relationship between cerebral perfusion pressure (CPP) and cerebral blood
flow is unclear in preeclampsia. Our objective was to clarify this issue by comparing normal …

There are conflicting evidence regarding the association of hypertension with Alzheimer's
disease (AD), and so far it is still unexplored whether increased blood pressure levels can …

Sleep has evolved as a universal core function to allow for restorative biological processes.
Detailed knowledge of metabolic changes necessary for the sleep state in the brain is …

Type I glutaric aciduria (GA1) is an inborn error of organic acid metabolism that is associated
with acute neurological crises, typically precipitated by an infectious illness. The …

Cationic amino acid (CAA) transport is brought about by two families of proteins that are
found in various tissues: Cat (CAA transporter), referred to as system y+, and Bat [broad …

Abstract Purpose: Cancer-testis (CT) antigens are often expressed in a proportion of tumors
of various types. Their restricted normal tissue expression and immunogenicity make them …