Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: the role of Epstein–Barr virus and the gut–brain axis

K Hashimoto - Molecular Psychiatry, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a serious public …

Sex and gender differences in intensive care medicine

H Merdji, MT Long, M Ostermann, M Herridge… - Intensive care …, 2023 - Springer
Despite significant advancements in critical care medicine, limited attention has been given
to sex and gender disparities in management and outcomes of patients admitted to the …

An update on management of adult patients with acute respiratory distress syndrome: an official American Thoracic Society clinical practice guideline

N Qadir, S Sahetya, L Munshi, C Summers… - American journal of …, 2024 - atsjournals.org
Background: This document updates previously published Clinical Practice Guidelines for
the management of patients with acute respiratory distress syndrome (ARDS), incorporating …

Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage

C Beck, D Ramanujam, P Vaccarello… - Nature …, 2023 - nature.com
Recent studies of severe acute inflammatory lung disease including COVID-19 identify
macrophages to drive pulmonary hyperinflammation and long-term damage such as fibrosis …

Endothelial cell‐derived extracellular vesicles expressing surface VCAM1 promote sepsis‐related acute lung injury by targeting and reprogramming monocytes

L Wang, Y Tang, J Tang, X Liu, S Zi, S Li… - Journal of …, 2024 - Wiley Online Library
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common life‐
threatening syndrome with no effective pharmacotherapy. Sepsis‐related ARDS is the main …

METTL3‐mediated N6‐methyladenosine exacerbates ferroptosis via m6A‐IGF2BP2‐dependent mitochondrial metabolic reprogramming in sepsis‐induced acute lung …

H Zhang, D Wu, Y Wang, K Guo… - Clinical and …, 2023 - Wiley Online Library
Neutrophil extracellular traps (NETs), released by polymorphonuclear neutrophils (PMNs),
exert a robust antimicrobial function in infectious diseases such as sepsis. NETs also …

Acute organ injury and long-term sequelae of severe pneumococcal infections

KL Kruckow, K Zhao, DME Bowdish, CJ Orihuela - Pneumonia, 2023 - Springer
Streptococcus pneumoniae (Spn) is a major public health problem, as it is a main cause of
otitis media, community-acquired pneumonia, bacteremia, sepsis, and meningitis. Acute …

Overview of the potential use of fluvoxamine for COVID-19 and long COVID

K Hashimoto - Discover Mental Health, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) has presented a serious worldwide threat to
public health since its emergence in late 2019. From a safety point of view, drug repurposing …

A diagnostic model for sepsis-induced acute lung injury using a consensus machine learning approach and its therapeutic implications

Y Zheng, J Wang, Z Ling, J Zhang, Y Zeng… - Journal of Translational …, 2023 - Springer
Background A significant proportion of septic patients with acute lung injury (ALI) are
recognized late due to the absence of an efficient diagnostic test, leading to the postponed …

Alpha-linolenic acid pretreatment alleviates NETs-induced alveolar macrophage pyroptosis by inhibiting pyrin inflammasome activation in a mouse model of sepsis …

C Liu, Y Zhou, Q Tu, L Yao, J Li, Z Yang - Frontiers in Immunology, 2023 - frontiersin.org
Background Neutrophil extracellular traps (NETs) can cause acute lung injury (ALI)/acute
respiratory distress syndrome (ARDS) by inducing macrophage pyroptosis. The purpose of …