Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and
results are starting to come in. Some of these results are not so encouraging, as exemplified …

Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with
Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection …

M. tuberculosis and M. leprae are considered to be prototypical intracellular pathogens that
have evolved strategies to enable growth in the intracellular phagosomes. In contrast, we …

IL-17 is a cytokine produced by T cells in response to IL-23. Recent data support a new
subset of CD4 Th cells distinct from Th1 or Th2 cells that produce IL-17 and may contribute …

High Ag load in chronic viral infections has been associated with impairment of Ag-specific T
cell responses; however, the relationship between Ag load in chronic Mycobacterium …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of
morbidity and mortality in humans worldwide. Currently, the standard treatment for TB …

Few tools exist to assess replication of chronic pathogens during infection. This has been a
considerable barrier to understanding latent tuberculosis, and efforts to develop new …

Mycobacterium tuberculosis (Mtb) frequently establishes persistent infections that may be
facilitated by mechanisms that dampen immunity. T regulatory (T reg) cells, a subset of …

IL-10 is a potent immunomodulatory cytokine that affects innate and acquired immune
responses. The immunological consequences of IL-10 production during pulmonary …

Although clinically apparent metastasis is associated with late stages of cancer
development, micro-metastatic dissemination may be an early event. However, the fate of …