Tuberculosis (TB) is an ancient and deadly disease characterized by complex host-
pathogen dynamics playing out over multiple time and length scales and physiological …

Background Interferon (IFN)–γ response to region of difference (RD) 1 proteins (culture
filtrate 10 and early secreted antigenic target 6) or overlapping peptides is a novel …

Tuberculosis (TB) continues to pose a serious global health threat, and the current vaccine,
BCG, has variable efficacy. However, the development of a more effective vaccine is …

Multidrug chemotherapy for 6–9-months is one of the primary treatments in effective control
of tuberculosis, although the mechanisms underlying the persistence of its etiological agent …

Although infection with Mycobacterium tuberculosis (M. tb) induces a robust CD8 T cell
response, the role of CD8 T cells in the defense against M. tb, and the mechanisms behind …

Here we discuss the application of the zebrafish as a relatively new model host for the study
of mycobacterial pathogenesis. Recent advances in our understanding of host …

Multifunctional T cells expressing several cytokines in parallel are thought to play a crucial
role in protection against different infections. To characterize T cell cytokine patterns …

Rationale: Regimens recommended to treat latent tuberculosis infection (LTBI) are 3 to 9
months long. A 2-month rifampin+ pyrazinamide regimen is no longer recommended …

Rationale: Healthy household contacts (HHCs) of patients with active pulmonary
tuberculosis are exposed aerogenically to Mycobacterium tuberculosis (Mtb), thus permitting …

Gamma interferon (IFN-γ) is a key cytokine in host defense against intracellular
mycobacterial infection. It has been believed that both CD4 and CD8 T cells are the primary …