Impact of oxygen on pancreatic islet survival

H Komatsu, F Kandeel, Y Mullen - Pancreas, 2018 - journals.lww.com
Pancreatic islet transplantation is a promising treatment option for individuals with type 1
diabetes; however, maintaining islet function after transplantation remains a large challenge …

Preservation of the donor heart: from basic science to clinical studies

SM Minasian, MM Galagudza… - … and thoracic surgery, 2015 - academic.oup.com
The methods of donor heart preservation are aimed at minimizing graft dysfunction caused
by ischaemia–reperfusion injury (IRI) which inevitably occurs during the ex vivo transport …

Oxygen-generating microparticles downregulate HIF-1α expression, increase cardiac contractility, and mitigate ischemic injury

K Mandal, S Sangabathuni, R Haghniaz, S Kawakita… - Acta Biomaterialia, 2023 - Elsevier
Myocardial hypoxia is the low oxygen tension in the heart tissue implicated in many
diseases, including ischemia, cardiac dysfunction, or after heart procurement for …

Heart transplantation with donation after circulatory death: what have we learned from preclinical studies?

P Niederberger, E Farine, M Raillard… - Circulation: Heart …, 2019 - Am Heart Assoc
Heart transplantation remains the preferred option for improving quality of life and survival
for patients suffering from end-stage heart failure. Unfortunately, insufficient supply of …

Beneficial effects of the novel marine oxygen carrier M101 during cold preservation of rat and human pancreas

F Lemaire, S Sigrist, E Delpy, J Cherfan… - Journal of Cellular …, 2019 - Wiley Online Library
Ischaemia impairs organ quality during preservation in a time‐dependent manner, due to a
lack of oxygen supply. Its impact on pancreas and islet transplantation outcome has been …

Консервация донорского сердца: история и современность с позиции трансляционной медицины

СМ Минасян, ММ Галагудза, ЮВ Дмитриев… - Регионарное …, 2014 - microcirc.ru
Аннотация Консервация донорского сердца является актуальной проблемой
современной трансплантологии и кардиохирургии. Несмотря на достигнутые успехи …

Recent developments in persufflation for organ preservation

CG Min, KK Papas - Current Opinion in Organ Transplantation, 2018 - journals.lww.com
Persufflation is a promising, relatively simple, preservation technique that enables improved
oxygenation, which provides protection and improvement in the graft condition during …

Organomatics and organometrics: Novel platforms for long-term whole-organ culture

BG Bruinsma, ML Yarmush, K Uygun - Technology, 2014 - World Scientific
Organ culture systems are instrumental as experimental whole-organ models of physiology
and disease, as well as preservation modalities facilitating organ replacement therapies …

The condition of the rat myocardium and isolated sheep heart after prolonged 24-hour hypothermic preservation in a pressurized carbon monoxide–oxygen gas …

EE Fesenko, EL Gagarinsky, AS Averin, NV Grudinin… - Biophysics, 2020 - Springer
High organoprotective properties of a carbon monoxide (CO)–oxygen (O 2) gas mixture
were confirmed after prolonged (24-h) preservation of the papillary muscle and an isolated …

Protective effect of antiapoptosis potency of prolonged preservation by desiccation using high-pressure carbon monoxide on isolated rabbit hearts

PY Zhou, Z Zhang, YL Guo, ZZ Xiao, P Zhu… - Transplantation …, 2015 - Elsevier
Heart transplantation has been widely accepted as a therapy for end-stage heart failure.
Mitigation of ischemia-reperfusion injury by inhibiting the apoptotic process plays an …