Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Metastasis causes breast cancer-related mortality. Tumor-infiltrating neutrophils (TINs) inflict
immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance …

The pro-inflammatory state of macrophages, underpinned by their metabolic condition, is
essentially affecting their capacity of combating tumor cells. Here we find, via a pooled …

Mitochondria are central hubs of cellular metabolism and are tightly connected to signaling
pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other …

Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …

Macrophages undergo profound metabolic reprogramming upon sensing infectious and
sterile stimuli. This metabolic shift supports and regulates essential innate immune functions …

Sepsis is a challenging clinical syndrome caused by a dysregulated host response to
infection. Here, we identified an unexpected proseptic activity of aconitate decarboxylase 1 …

Itaconate, the product of the decarboxylation of cis-aconitate, regulates numerous biological
processes. We and others have revealed itaconate as a regulator of fatty acid β-oxidation …

Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the
therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the …