High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

Until fairly recently, proteases were considered primarily to be protein-degrading enzymes.
However, this view has dramatically changed and proteases are now seen as extremely …

Background—Hypertensive target organ damage, especially cardiac hypertrophy with heart
failure and arrhythmia, is a major source of morbidity and mortality. Angiotensin II, a major …

Angiotensin (Ang) II promotes renal infiltration by immunocompetent cells in double-
transgenic rats (dTGRs) harboring both human renin and angiotensinogen genes. To …

Vascular inflammation is involved in the initiation and progression of atherosclerosis, and is
also present in hypertension-and diabetes-induced vascular complications. Angiotensin II …

Renin was first isolated in the kidney by Tigerstedt and Bergman over 100 years ago. Almost
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …

Circulating monocytes and tissue macrophages play complex roles in the pathogenesis of
hypertension, a highly prevalent disease associated with catastrophic cardiovascular …

We compared the effect n-3 polyunsaturated fatty acids (PUFAs) with direct renin inhibition
on electrophysiological remodeling in angiotensin II–induced cardiac injury. We treated …

The first evidence of the existence of renin was presented over 100 years ago. However, the
importance of renin and the renin–angiotensin system in the pathogenesis of cardiovascular …

We tested the hypothesis that the renin inhibitor aliskiren ameliorates organ damage in rats
transgenic for human renin and angiotensinogen genes (double transgenic rat [dTGR]). Six …