Neutralizing antibodies (nAbs) are being increasingly used as passive antiviral reagents in
prophylactic and therapeutic modalities and to guide viral vaccine design. In vivo, nAbs can …

Alphaviruses are arthropod-transmitted RNA viruses that cause epidemics of human
infection and disease on a global scale. These viruses are classified as either arthritogenic …

DNA viruses often persist in the body of their host, becoming latent and recurring many
months or years later. By contrast, most RNA viruses cause acute infections that are cleared …

Chikungunya virus (CHIKV) is a representative alphavirus causing debilitating arthritogenic
disease in humans. Alphavirus particles assemble into two icosahedral layers: the …

Antibodies have been used to prevent or treat viral infections since the nineteenth century,
but the full potential to use passive immunization for infectious diseases has yet to be …

The brutal toll of another viral pandemic can be blunted by investing now in research that
uncovers mechanisms of broad-based immunity so we may have vaccines and therapeutics …

Abstract The Togaviridae family, genus, Alphavirus, includes several mosquito-borne human
pathogens with the potential to spread to near pandemic proportions. Most of these are …

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics of
acute and chronic musculoskeletal disease. Here, we analyzed the human B cell response …

Antibodies are frontline defenders against influenza virus infection, providing protection
through multiple complementary mechanisms. Although a subset of monoclonal antibodies …

Venezuelan equine encephalitis virus (VEEV) remains a risk for epidemic emergence or use
as an aerosolized bioweapon. To develop possible countermeasures, we isolated VEEV …