Secretion of bicarbonate into the adherent layer of mucus gel creates a pH gradient with a
near-neutral pH at the epithelial surfaces in stomach and duodenum, providing the first line …

The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

Intestinal oxalate transport, mediated by anion exchange proteins, is important to oxalate
homeostasis and consequently to calcium oxalate stone diseases. To assess the …

Epithelial cells of the gastrointestinal tract are an important barrier between the “milieu
interne” and the luminal content of the gut. They perform transport of nutrients, salts, and …

HCO3− secretion by gastric mucous cells is essential for protection against acidic injury and
peptic ulcer. Herein we report the identification of an apical HCO3− transporter in gastric …

Neuronal activity results in significant pH shifts in neurons, glia, and interstitial space.
Several transport mechanisms are involved in the fine-tuning and regulation of extra-and …

We hypothesized that duodenal HCO3− secretion alkalinizes the microclimate surrounding
intestinal alkaline phosphatase (IAP), increasing its activity. We measured AP activity in rat …

Copper is an essential micronutrient in humans and is required for a wide range of
physiological processes, including neurotransmitter biosynthesis, oxidative metabolism …

The solute carrier SLC4 family consists of 10 members, nine of which are HCO 3-
transporters, including three Na+-independent Cl−/HCO 3-exchangers AE1, AE2, and AE3 …

Basal HCO3− secretion across the duodenum has been shown in several species to
principally involve the activity of apical membrane Cl−/HCO3− exchanger (s). To investigate …