5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Background The nonselective 5‐HT 4 receptor agonists, cisapride and tegaserod have been
associated with cardiovascular adverse events (AEs). Aim To perform a systematic review of …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Covers all aspects of the structure, function, neurochemistry, transmitter identification and
development of the enteric nervous system This book brings together extensive knowledge …

BACKGROUND & AIMS: 5-hydroxytryptamine receptor (5-HT4R) agonists promote
gastrointestinal motility and attenuate visceral pain, but concerns about adverse reactions …

Although the mature enteric nervous system (ENS) has been shown to retain stem cells,
enteric neurogenesis has not previously been demonstrated in adults. The relative number …

Serotonin (5-HT) is an important signaling molecule in the gut targeting enterocytes, smooth
muscles and enteric neurons. Most of the body serotonin is present in enterochromaffin …

The human cardiovascular system is exposed to plasma 5-hydroxytryptamine (5-HT,
serotonin), usually released from platelets. 5-HT can produce harmful acute and chronic …

Background Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal
tract characterized by abdominal discomfort, pain and changes in bowel habits, often …

Hydroxytryptamine4 (5‐HT4) receptors are an interesting target for the management of
patients in need of gastrointestinal (GI) promotility treatment. They have proven therapeutic …