Extracellular vesicles: a rising star for therapeutics and drug delivery

S Du, Y Guan, A Xie, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Extracellular vesicle heterogeneity and its impact for regenerative medicine applications

SI Van De Wakker, FM Meijers, JPG Sluijter… - Pharmacological …, 2023 - ASPET
Extracellular vesicles (EVs) are cell-derived membrane-enclosed particles that are involved
in physiologic and pathologic processes. EVs are increasingly being studied for therapeutic …

[HTML][HTML] Engineered mesenchymal stem cell-derived extracellular vesicles: a state-of-the-art multifunctional weapon against Alzheimer's disease

T Yin, Y Liu, W Ji, J Zhuang, X Chen, B Gong, J Chu… - Theranostics, 2023 - ncbi.nlm.nih.gov
With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine

Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in
intracellular communication through EV-encapsulated informative content, including …

[HTML][HTML] Role of regenerative medicine in the treatment of diseases

E Rahmani, M Rezaei, R Tavakoli, E Ghadirzadeh… - Kindle, 2023 - preferpub.org
Regenerative medicine is a rapidly advancing field that aims to restore, replace, or
regenerate damaged tissues and organs using advanced biomedical techniques. Its …

Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application

Q Yang, S Li, H Ou, Y Zhang, G Zhu, S Li… - Journal of …, 2024 - Springer
Malignancy is a major public health problem and among the leading lethal diseases
worldwide. Although the current tumor treatment methods have therapeutic effect to a certain …

Advancements in engineered exosomes for wound repair: current research and future perspectives

H Ye, F Wang, G Xu, F Shu, K Fan… - … in Bioengineering and …, 2023 - frontiersin.org
Wound healing is a complex and prolonged process that remains a significant challenge in
clinical practice. Exosomes, a type of nanoscale extracellular vesicles naturally secreted by …

Engineering of MSC-derived exosomes: a promising cell-free therapy for osteoarthritis

J Cheng, Y Sun, Y Ma, Y Ao, X Hu, Q Meng - Membranes, 2022 - mdpi.com
Osteoarthritis (OA) is characterized by progressive cartilage degeneration with increasing
prevalence and unsatisfactory treatment efficacy. Exosomes derived from mesenchymal …

Mesenchymal stem cell-derived extracellular vesicles: An emerging diagnostic and therapeutic biomolecules for neurodegenerative disabilities

M Kandeel, MA Morsy, KM Alkhodair, S Alhojaily - Biomolecules, 2023 - mdpi.com
Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various
organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of …

Mesenchymal stem cell-derived extracellular vesicles: a potential therapy for diabetes mellitus and diabetic complications

F Sun, Y Sun, F Wu, W Xu, H Qian - Pharmaceutics, 2022 - mdpi.com
As a novel cell-free strategy, mesenchymal stem cell-derived extracellular vesicles (MSC-
EVs) inherit the therapeutic potential of donor cells, and are widely used for the treatment of …