Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …

Introduction Unexpected non-apparent and hidden allosteric-binding sites are non-classical
and non-apparent allosteric centers in 3-D X-ray protein structures until orthosteric or …

Drug overdose deaths involving cocaine have skyrocketed, an outcome attributable in part
to the lack of FDA-approved medications for the treatment of cocaine use disorder (CUD) …

A critical aspect of drug development in the therapy of neuropsychiatric diseases is the
“Target Problem”, that is, the selection of a proper target after not simply the etiopathological …

Flow is an intrinsically rewarding state characterised by positive affect and total task
absorption. Because cognitive and physical performance are optimal in flow, chemical …

Antipsychotics share the common pharmacological feature of antagonizing the dopamine 2
receptor (D2R), which is abundant in the striatum and involved in both the therapeutic and …

Abstract Introduction Adenosine 2A (A2A) receptors co-localize with dopamine D2 receptors
in striatopallidal medium spiny neurons of the indirect pathway. A2A receptor activation in …

Obsessive-compulsive disorder (OCD) is characterized by recurring obsessive thoughts and
repetitive behaviors that are often associated with anxiety and perturbations in cortico …