Healthy limb joints are important for maintaining health and attaining longevity.
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …

Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

Osteoarthritis (OA) is an urgent public health problem; however, the underlying causal
mechanisms remain unclear, especially in terms of inflammatory mediators in cartilage …

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading
articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA …

We previously identified 529 proteins that had been reported by multiple different studies to
change their expression level with age in human plasma. In the present study, we measured …

Osteoarthritis (OA), the most common aging-related joint disease, is caused by an
imbalance between extracellular matrix synthesis and degradation. Here, we discover that …

Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the
cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that …

The Runt-related transcription factor (Runx) family plays various roles in the homeostasis of
cartilage. Here, we examined the role of Runx2 and Runx3 for osteoarthritis development in …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

Objective In this review, we have highlighted advances in genetics, genomics and
epigenetics in the field of osteoarthritis (OA) over the past year. Methods A literature search …