Chronic cough is defined in adults as a cough that lasts for≥ 8 weeks. When it proves
intractable to standard-of-care treatment, it can be referred to as refractory chronic cough …

Communication problems (eg, dysphonia, dysfluency and language and articulation
disorders), swallowing disorders (dysphagia and globus), cough and upper airway …

Background ATP acting via P2X3 receptors is an important mediator of refractory chronic
cough (RCC). This phase 2a double-blinded crossover study assessed the safety …

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …

Abstract ATP-dependent P2X3 receptors play a crucial role in the sensitization of nerve
fibers and pathological pain pathways. They are also involved in pathways triggering cough …

Chronic cough, defined as a cough lasting> 8 weeks, is a common medical condition that
exerts a substantial physical, mental, and social burden on patients. A subset of patients with …

BLU-5937 is a small molecule that was shown to be a potent, selective and non-competitive
P2X3 homotrimeric receptor antagonist. P2X3 receptors are ATP ion-gated channels located …

Background P2X3 receptor antagonists seem to have a promising potential for treating
patients with refractory chronic cough. In this double-blind, randomized, placebo-controlled …

Chronic cough is common in the community and causes significant morbidity. Several
factors may underlie this problem, but comorbid conditions located at sensory nerve endings …

Refractory chronic cough (RCC) and unexplained chronic cough (UCC) are common
problems seen in primary care and subspecialty clinics. The role of cough hypersensitivity …