Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

Peptide dendrimers are radial or wedge-like branched macromolecules consisting of a
peptidyl branching core and/or covalently attached surface functional units. The multimeric …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that
originated in Wuhan, China, in December 2019 has impacted public health, society, the …

Abstract Within 25 years after zidovudine (3′‐azido‐2′, 3′‐dideoxythymidine, AZT) was
first described as an inhibitor of HIV replication, 25 anti‐HIV drugs have been formally …

Attachment of microbial protein to host cell-surface carbohydrate is considered essential for
successful infection. Information of conceptual interest, including crystal structures of protein …

This book provides basic principles of multivalent interactions found in biological systems as
well as an up-to-date and thorough coverage in design concepts, syntheses, and biological …

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes severe and often
persistent arthritis. In recent years, millions of people have been infected with this virus for …

Virus-cell interactions involve fundamental parameters that need to be considered in
strategies implemented to control viral outbreaks. Among these, the surface electrostatic …

The goals for the development of multiple antigen peptides (MAP) are to provide a rational
and unambiguous system to multimerize different types of synthetic peptide antigens and to …

Insight into the mode of action of newly discovered antiviral agents is now almost a
prerequisite for clinical development. This protocol describes a method that provides …