Orofacial clefts (OFCs) rank as the second most common congenital birth defect in the
United States after Down syndrome and are the most common head and neck congenital …

The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

Craniofacial development involves several complex tissue movements including several
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …

Non syndromic orofacial clefts specifically non-syndromic cleft lip/palate are one of the most
common craniofacial malformation among birth defects in human having multifactorial …

To investigate the origins and stages of vertebrate adaptive radiation, we reconstructed the
spatial and temporal histories of adaptive alleles underlying major phenotypic axes of …

Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

The mammalian lip and primary palate form when coordinated growth and morphogenesis
bring the nasal and maxillary processes into contact, and the epithelia co-mingle, remodel …

Canalization, or robustness to genetic or environmental perturbations, is fundamental to
complex organisms. While there is strong evidence for canalization as an evolved property …

Tooth agenesis and orofacial clefts represent the most common developmental anomalies
and their co-occurrence is often reported in patients as well in animal models. The aim of the …

Recent studies have shown how volumetric imaging and morphometrics can add
significantly to our understanding of morphogenesis, the developmental basis for variation …