The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Many physiological processes are regulated with a 24-h periodicity to anticipate the
environmental changes of daytime to nighttime and vice versa. These 24-h regulations …

Cellular dynamics and fate decision in early human embryogenesis remain largely unknown
owing to the challenges of performing studies in human embryos. Here, we explored whole …

BACKGROUND The concept of developmental programming suggests that the early life
environment influences offspring characteristics in later life, including the propensity to …

Mitochondria are the most abundant organelles in the mammalian oocyte and early embryo.
While their role in ATP production has long been known, only recently has their contribution …

Mitochondria are fundamental organelles in eukaryotic cells that provide ATP through
oxidative phosphorylation. During this process, reactive oxygen species (ROS) are …

Obesity is associated with ovulatory disorders, decreased rates of conception, infertility,
early pregnancy loss and congenital abnormalities. Poor oocyte quality and reduced IVF …

The aim of this study was to evaluate the distribution of inhibin/activin alpha, beta (A) and
beta (B) subunits and follistatin in immature oocytes and in matured oocytes before and after …

Mitochondrial metabolic capacity and DNA replication have both been shown to affect
oocyte quality, but it is unclear which one is more critical. In this study, immature oocytes …

The role of mitochondria as central determinants of development competence of oocytes
and preimplantation stage embryos is considered in the context of the diverse activities …