Sepsis-associated encephalopathy (SAE) is commonly complicated by septic conditions,
and is responsible for increased mortality and poor outcomes in septic patients …

The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with
conserved production in prokaryotes and eukaryotes and a wide range of functions. In the …

Targeting tumor-associated macrophages (TAMs) is a promising strategy to modify the
immunosuppressive tumor microenvironment and improve cancer immunotherapy …

Neurotransmitters are biologically active molecules that are crucial for the regulation of
normal physiological functions in the central and peripheral nervous systems. Therefore …

Exercise, stress, sleep and diet are four distinct but intertwined lifestyle factors that influence
the cardiovascular system. Abundant epidemiological, clinical and preclinical studies have …

Recent studies have demonstrated that tissue homeostasis and metabolic function are
dependent on distinct tissue-resident immune cells that form functional cell circuits with …

The classical liver-derived and serum-effective complement system is well appreciated as a
key mediator of host protection via instruction of innate and adaptive immunity. However …

Detecting danger is key to the survival and success of all species. Animal nervous and
immune systems cooperate to optimize danger detection. Preceding studies have …

Beneficial effect of regular moderate physical exercise (PE) and negative effect of severe
exercise and/or overtraining as an activator of the sympathetic nervous system (SNS) have …

Endocrine, nervous, and immune systems work coordinately to maintain the global
homeostasis of the organism. They show sex differences in their functions that, in turn …