Craniosynostosis is a major congenital craniofacial disorder characterized by the premature
fusion of cranial suture (s). Patients with severe craniosynostosis often have impairments in …

Craniosynostosis is a developmental craniofacial anomaly, resulting in impairment of brain
development and abnormally shaped skull. The main cause of craniosynostosis is …

Bone tissue undergoes constant turnover supported by stem cells. Recent studies showed
that perivascular mesenchymal stem cells (MSCs) contribute to the turnover of long bones …

Craniosynostosis results from the premature fusion of cranial sutures, with an incidence of 1
in 2,100-2,500 live births. The majority of cases are non-syndromic and involve single suture …

This article provides an overview of the diagnosis and management of infants and children
with craniofacial syndromes. Treatment protocols from The Hospital for Sick Children …

Background: A multidisciplinary meeting was held from March 4 through 6, 2010, in Atlanta,
Georgia, to conceptualize, map out, and operationalize the variables most relevant to the …

Crouzon syndrome exhibits considerable phenotypic heterogeneity, in the aetiology of
which genetics play an important role. FGFR2 mediates extracellular signals into cells and …

Bone grafts are medical devices that are in high demand in clinical practice for substitution
of bone defects and recovery of atrophic bone regions. Based on the analysis of the modern …

Background To date, few studies have explored the effects of exposure to metal mixtures on
adverse developmental outcomes, and no reported studies have linked metal exposure to …

Fibroblast growth factor receptor 2 (FGFR2) in craniofacial bones mediates osteoprogenitor
proliferation, differentiation, and apoptosis. The distortion of proper craniofacial bone growth …