T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy

G Ghilardi, JA Fraietta, JN Gerson, VM Van Deerlin… - Nature Medicine, 2024 - nature.com
We report a T cell lymphoma (TCL) occurring 3 months after anti-CD19 chimeric antigen
receptor (CAR) T cell immunotherapy for non-Hodgkin B cell lymphoma. The TCL was …

Unanswered questions following reports of secondary malignancies after CAR-T cell therapy

BL Levine, MC Pasquini, JE Connolly, DL Porter… - nature medicine, 2024 - nature.com
Unanswered questions following reports of secondary malignancies after CAR-T cell therapy |
Nature Medicine Skip to main content Thank you for visiting nature.com. You are using a browser …

Current understanding and management of CAR T cell-associated toxicities

JN Brudno, JN Kochenderfer - Nature Reviews Clinical Oncology, 2024 - nature.com
Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of several
haematological malignancies and is being investigated in patients with various solid …

Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy

MP Hamilton, T Sugio, T Noordenbos… - … England Journal of …, 2024 - Mass Medical Soc
Background The risk of second tumors after chimeric antigen receptor (CAR) T-cell therapy,
especially the risk of T-cell neoplasms related to viral vector integration, is an emerging …

Bispecific antibodies and CAR-T cells: dueling immunotherapies for large B-cell lymphomas

A Trabolsi, A Arumov, JH Schatz - Blood Cancer Journal, 2024 - nature.com
Despite recent advances in frontline therapy for diffuse large B-cell lymphoma (DLBCL), at
least a third of those diagnosed still will require second or further lines for relapsed or …

Naturally occurring T cell mutations enhance engineered T cell therapies

J Garcia, J Daniels, Y Lee, I Zhu, K Cheng, Q Liu… - Nature, 2024 - nature.com
Adoptive T cell therapies have produced exceptional responses in a subset of patients with
cancer. However, therapeutic efficacy can be hindered by poor T cell persistence and …

[PDF][PDF] Answering the “Doctor, can CAR-T therapy cause cancer?” question in clinic

R Banerjee, C Poh, AV Hirayama, J Gauthier… - Blood …, 2024 - ashpublications.org
COI notes: Competing interests: RB reports consulting: BMS, Caribou Biosciences,
Genentech, Janssen, Pfizer, Sanofi, SparkCures; Research: Novartis, Pack Health. CP …

The Fate (s) of CAR T-Cell Therapy: Navigating the Risks of CAR+ T-Cell Malignancy

M Abou-el-Enein - Blood Cancer Discovery, 2024 - AACR
The introduction of chimeric antigen receptor (CAR) T-cell therapy represents a landmark
advancement in treating resistant forms of cancer such as leukemia, lymphoma, and …

[PDF][PDF] Risk of T-cell Malignancy Following CAR T cells in Children, Adolescents and Young Adults

AJ Lamble, LM Schultz, K Nguyen, EM Hsieh… - Blood …, 2024 - ashpublications.org
COI notes: NNS receives research funding from Lentigen, VOR Bio, and CARGO
Therapeutics. NNS has attended advisory board meetings (no honoraria) for VOR …

Comparison of Comorbidity Models Within a Population-Based Cohort of Older Adults With Non-Hodgkin Lymphoma

MJ Gordon, Z Duan, H Zhao, L Nastoupil… - JCO Clinical Cancer …, 2024 - ascopubs.org
PURPOSE Compare the association of individual comorbidities, comorbidity indices, and
survival in older adults with non-Hodgkin lymphoma (NHL), including in specific NHL …