Cholinergic synapses are ubiquitous in the human central nervous system. Their high
density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic …

This comprehensive practice parameter for allergic rhinitis (AR) and nonallergic rhinitis
(NAR) provides updated guidance on diagnosis, assessment, selection of monotherapy and …

Importance Urinary incontinence, the involuntary loss of urine, is a common health condition
that may decrease quality of life. Ten to twenty percent of women and up to 77% of women …

Introduction Subjective cognitive decline (SCD) manifesting before clinical impairment could
serve as a target population for early intervention trials in Alzheimer's disease (AD). A …

Background Leuco-methylthioninium bis (hydromethanesulfonate; LMTM), a stable reduced
form of the methylthioninium moiety, acts as a selective inhibitor of tau protein aggregation …

Abstract Context The European Association of Urology guidelines on urinary incontinence
(UI) have been updated in cyclical fashion with successive major chapters being revised …

A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

Objectives To estimate the association between the duration and level of exposure to
different classes of anticholinergic drugs and subsequent incident dementia. Design Case …

Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued
development and standardization of methodologies for biomarkers and has provided an …

Lower urinary tract dysfunction is a common sequel of neurological disease resulting in
symptoms that significantly impacts quality of life. The site of the neurological lesion and its …