A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery

PN Kalaria, SC Karad, DK Raval - European journal of medicinal chemistry, 2018 - Elsevier
The upward extend of malaria collectively with the emergence of resistance against
predictable drugs has put enormous pressure on public health systems to introduce new …

Recent advances in Stetter reaction and related chemistry: an update

MM Heravi, V Zadsirjan… - Asian Journal of …, 2020 - Wiley Online Library
The Stetter reaction is actually a special C− C bond forming reaction through a 1, 4‐addition
reaction in the presence of nucleophilic catalyst. It involves a reaction between aldehydes …

Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore

A Husain, SA Khan, F Iram, MA Iqbal, M Asif - European Journal of …, 2019 - Elsevier
Furanone, a five-membered heteroaromatic ring containing oxygen atom, is of immense
pharmaceutical importance. Presence of this nucleus in biologically active compounds of …

The current status of O‐heterocycles: A synthetic and medicinal overview

PK Singh, O Silakari - ChemMedChem, 2018 - Wiley Online Library
O‐Heterocycles have been explored in the field of medicinal chemistry for a long time, but
their significance has not been duly recognised and they are often shunned in favour of N …

Synthesis of 1, 4‐Dicarbonyl Compounds via Visible‐Light‐Induced Decarboxylative Radical Cascade Reactions

Z Su, J Zhang, HW Lin, H Liao - Advanced Synthesis & …, 2023 - Wiley Online Library
We herein report a method for the synthesis of 1, 4‐dicarbonyl compounds using light‐
activated electron donor‐acceptor (EDA) complexes. This multi‐component reaction …

Recent advances in synthesis and biological assessment of quinoline‐oxygen heterocycle hybrids

G Kumar, B Saroha, R Kumar, M Kumari… - …, 2021 - Wiley Online Library
The exploration of hybrid molecules for targeting various diseases represents a highly
promising approach which has showcased significant momentum worldwide, in the last two …

Rh-Catalyzed Carbonylative Cyclization of Propargylic Alcohols with Aryl Boronic Acids

W He, WF Zheng, H Qian - Organic Letters, 2024 - ACS Publications
2 (3 H)-Furanones are tremendously important not only because of their wide occurrence in
bioactive compounds but also due to their versatility in organic synthesis. Here, a …

Light-Driven Three-Component Carbonylation of Aryl Halides Using Abundant Metal Carbonyl

Q Mou, T Han, M Liu - Organic Letters, 2024 - ACS Publications
Carbonyl compounds are widely found in various pharmaceutical intermediates and
synthetic precursors. Herein we report a simple light-driven three-component aryl halide …

Design, synthesis and biological evaluation of mono-and bisquinoline methanamine derivatives as potential antiplasmodial agents

FRB Bokosi, RM Beteck, M Mbaba, TE Mtshare… - Bioorganic & Medicinal …, 2021 - Elsevier
Several classes of antimalarial drugs are currently available, although issues of toxicity and
the emergence of drug resistant malaria parasites have reduced their overall therapeutic …

A structure guided drug-discovery approach towards identification of Plasmodium inhibitors

B Aneja, B Kumar, MA Jairajpuri, M Abid - RSC advances, 2016 - pubs.rsc.org
Rapidly increasing resistance to the currently available antimalarial drugs has drawn
attention globally for the search for more potent novel drugs with a high therapeutic index …