A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery
The upward extend of malaria collectively with the emergence of resistance against
predictable drugs has put enormous pressure on public health systems to introduce new …
predictable drugs has put enormous pressure on public health systems to introduce new …
Recent advances in Stetter reaction and related chemistry: an update
MM Heravi, V Zadsirjan… - Asian Journal of …, 2020 - Wiley Online Library
The Stetter reaction is actually a special C− C bond forming reaction through a 1, 4‐addition
reaction in the presence of nucleophilic catalyst. It involves a reaction between aldehydes …
reaction in the presence of nucleophilic catalyst. It involves a reaction between aldehydes …
Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore
Furanone, a five-membered heteroaromatic ring containing oxygen atom, is of immense
pharmaceutical importance. Presence of this nucleus in biologically active compounds of …
pharmaceutical importance. Presence of this nucleus in biologically active compounds of …
The current status of O‐heterocycles: A synthetic and medicinal overview
PK Singh, O Silakari - ChemMedChem, 2018 - Wiley Online Library
O‐Heterocycles have been explored in the field of medicinal chemistry for a long time, but
their significance has not been duly recognised and they are often shunned in favour of N …
their significance has not been duly recognised and they are often shunned in favour of N …
Synthesis of 1, 4‐Dicarbonyl Compounds via Visible‐Light‐Induced Decarboxylative Radical Cascade Reactions
Z Su, J Zhang, HW Lin, H Liao - Advanced Synthesis & …, 2023 - Wiley Online Library
We herein report a method for the synthesis of 1, 4‐dicarbonyl compounds using light‐
activated electron donor‐acceptor (EDA) complexes. This multi‐component reaction …
activated electron donor‐acceptor (EDA) complexes. This multi‐component reaction …
Recent advances in synthesis and biological assessment of quinoline‐oxygen heterocycle hybrids
The exploration of hybrid molecules for targeting various diseases represents a highly
promising approach which has showcased significant momentum worldwide, in the last two …
promising approach which has showcased significant momentum worldwide, in the last two …
Rh-Catalyzed Carbonylative Cyclization of Propargylic Alcohols with Aryl Boronic Acids
W He, WF Zheng, H Qian - Organic Letters, 2024 - ACS Publications
2 (3 H)-Furanones are tremendously important not only because of their wide occurrence in
bioactive compounds but also due to their versatility in organic synthesis. Here, a …
bioactive compounds but also due to their versatility in organic synthesis. Here, a …
Light-Driven Three-Component Carbonylation of Aryl Halides Using Abundant Metal Carbonyl
Q Mou, T Han, M Liu - Organic Letters, 2024 - ACS Publications
Carbonyl compounds are widely found in various pharmaceutical intermediates and
synthetic precursors. Herein we report a simple light-driven three-component aryl halide …
synthetic precursors. Herein we report a simple light-driven three-component aryl halide …
Design, synthesis and biological evaluation of mono-and bisquinoline methanamine derivatives as potential antiplasmodial agents
Several classes of antimalarial drugs are currently available, although issues of toxicity and
the emergence of drug resistant malaria parasites have reduced their overall therapeutic …
the emergence of drug resistant malaria parasites have reduced their overall therapeutic …
A structure guided drug-discovery approach towards identification of Plasmodium inhibitors
Rapidly increasing resistance to the currently available antimalarial drugs has drawn
attention globally for the search for more potent novel drugs with a high therapeutic index …
attention globally for the search for more potent novel drugs with a high therapeutic index …