Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

[HTML][HTML] Natural therapeutics in aid of treating alzheimer's disease: a green gateway toward ending quest for treating neurological disorders

BA Bhat, A Almilaibary, RA Mir, BM Aljarallah… - Frontiers in …, 2022 - frontiersin.org
The current scientific community is facing a daunting challenge to unravel reliable natural
compounds with realistic potential to treat neurological disorders such as Alzheimer's …

Natural Anti-inflammatory compounds as Drug candidates in Alzheimer's disease

RH Mir, AJ Shah, R Mohi-Ud-Din… - Current medicinal …, 2021 - ingentaconnect.com
Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by
memory impairment, dementia, and oxidative stress in elderly people. Currently, only a few …

Therapeutic applications of apigenin and its derivatives: micro and nano aspects

H Javid, S Ahmadi, E Mohamadian - Micro Nano Bio Aspects, 2023 - mnba-journal.com
Antibacterial, antifungal, antiviral, antiparasitic, antioxidant, antiangiogenic, antitumor,
antidiabetic, antihyperlipidemic, and antineurodegenerative properties have been indicated …

[HTML][HTML] Apigenin ameliorates scopolamine-induced cognitive dysfunction and neuronal damage in mice

Y Kim, J Kim, M He, A Lee, E Cho - Molecules, 2021 - mdpi.com
We investigated the protective effect and mechanisms of apigenin against cognitive
impairments in a scopolamine-injected mouse model. Our results showed that …

Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms

Z Mushtaq, NB Sadeer, M Hussain… - … Journal of Food …, 2023 - Taylor & Francis
ABSTRACT Apigenin (4,'5, 7-trihydroxyflavone) is one of the most studied flavonoids with
low toxicity and abundantly present phenolic compound in the plant kingdom. The main …

Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer's disease: Flavonoids and phenols

M Zhang, G Hu, N Shao, Y Qin, Q Chen, Y Wang… - …, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid plaques
and tangles that have become the fifth leading cause of death worldwide. Previous studies …

[HTML][HTML] Ameliorative Effects of Rhoifolin in Scopolamine-Induced Amnesic Zebrafish (Danio rerio) Model

I Brinza, AM Abd-Alkhalek, MA El-Raey, RS Boiangiu… - Antioxidants, 2020 - mdpi.com
Rhoifolin (Rho) exerts many biological activities such as anticancer, antidiabetic,
hepatoprotective, antirheumatic, antibacterial, and antiviral properties. The neuroprotective …

Beneficial effects of apigenin on the transgenic Drosophila model of Alzheimer's disease

YH Siddique, G Ara, M Afzal, H Varshney… - Chemico-Biological …, 2022 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. The available drugs
improve the symptoms but do not play role in modifying disease effects. Currently, the …

The Beneficial Role of Apigenin against Cognitive and Neurobehavioural Dysfunction: A Systematic Review of Preclinical Investigations

TA Olasehinde, OO Olaokun - Biomedicines, 2024 - mdpi.com
Apigenin is a flavone widely present in different fruits and vegetables and has been
suggested to possess neuroprotective effects against some neurological disorders. In this …