Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Photodynamic therapy (PDT) has been extensively investigated for decades for tumor
treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and …

Cancer immunotherapy has emerged as a novel cancer treatment, although recent
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

Breast cancer is the most commonly diagnosed cancer in women. Metastasis is the primary
cause of mortality for breast cancer patients. Multiple mechanisms underlie breast cancer …

The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Suppression of antitumor immune responses is one of the main mechanisms by which tumor
cells escape from destruction by the immune system. Myeloid-derived suppressor cells …

Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …

Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …