Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …

Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …

Human Cytochrome P450 (CYP) enzymes constitute a superfamily of membrane-bound
hemoproteins that are responsible for the metabolism of a wide variety of clinically …

The cytochrome P450 (CYP) enzymes are a diverse group of heme monooxygenases that,
through the course of their reaction cycle, can contribute to cellular reactive oxygen species …

Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical
presentations that can escalate to acute liver failure. The worldwide increase in the use of …

Cytochrome P450 (CYP) enzymes are responsible for the biotransformation of drugs,
xenobiotics, and endogenous substances. This enzymatic activity can be modulated by …

Cytochrome P450s (CYPs), heme-containing monooxygenases, play important roles in a
wide variety of metabolic processes important for development as well as biotic/trophic …

The administered dose of a drug modulates whether patients will experience optimal
effectiveness, toxicity including death, or no effect at all. Dosing is particularly important for …

Precisely controlled deuterium labeling at specific sites of N-alkyl drugs is crucial in drug-
development as over 50% of the top-selling drugs contain N-alkyl groups, in which it is very …

Luminogenic cytochrome P450 (CYP) assays couple CYP enzyme activity to firefly
luciferase luminescence in a technology called P450-GloTM (Promega). Luminogenic …