Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage loss
and accounts for a major source of pain and disability worldwide. However, effective …

Mesenchymal stem cell-derived exosomes (MSC-Exos) have been utilized as medicinal
agents or as delivery vehicles in cartilage injuries and cartilage-based diseases. Given the …

Objective Our previous studies revealed that normal synovial exosomes promoted
chondrogenesis, and microRNA (miR)-19b-3p independently related to osteoarthritis (OA) …

Osteoarthritis (OA) is one of the most common refractory degenerative joint diseases
worldwide. Synovitis is believed to drive joint cartilage destruction during OA pathogenesis …

The use of mesenchymal stem cells constitutes a promising therapeutic approach, as it has
shown beneficial effects in different pathologies. Numerous in vitro, pre-clinical, and, to a …

The mechanism of temporomandibular joint osteoarthritis (TMJOA), which leads to the final
erosion of cartilage and subchondral bone, has been widely demonstrated, but still not …

Background Investigation of cartilage and chondrocytes has revealed that the osteoarthritis
risk marked by the independent DNA variants rs11583641 and rs1046934 mediate their …

Macrophages are the most important innate immune cells in humans. They are almost
ubiquitous in peripheral tissues with a large variety of different mechanical milieus …

The ultimate goal of molecular genetic studies of human diseases is to translate the
discoveries for patient benefit. For diseases that lack licensed disease-modifying …