Intervertebral disc degeneration (IVDD) is a main cause of lower back pain, leading to
psychological and economic burdens to patients. Physical therapy only delays pain in …

Extracellular vesicles comprise an as yet inadequately investigated intercellular
communication pathway in the field of early osteoarthritis. We hypothesised that the small …

The ultimate goal of molecular genetic studies of human diseases is to translate the
discoveries for patient benefit. For diseases that lack licensed disease-modifying …

Osteoarthritis (OA) is a painful joint disease that is common among the middle-aged and
elderly populations, with an increasing prevalence. Therapeutic options for OA are limited …

Background Investigation of cartilage and chondrocytes has revealed that the osteoarthritis
risk marked by the independent DNA variants rs11583641 and rs1046934 mediate their …

Osteoarthritis (OA) is the most common degenerative joint disease that causes chronic pain
and disability. Different innate immune components, including macrophages, T cells, and …

Osteoarthritis (OA) is a degenerative disease caused by the progressive destruction of
cartilage and subchondral bone [1]. Studies have shown that by inhibiting the degradation of …

Osteoarthritis (OA) remains a challenging condition due to limited drug bioavailability within
the avascular and dense cartilage matrix. This study introduces a pH/redox-responsive …

Background: Clinical trials are currently underway to investigate the efficacy of intra-articular
administration of mesenchymal stromal cells (MSCs) to mitigate osteoarthritis (OA) …

Breast cancer has a heavy toll on the world's health, both in terms of morbidity and death.
For women aged 35 to 54, it is the primary cause of mortality. In addition, over the preceding …