Calcium release-activated calcium channels and pain
Y Mei, JE Barrett, H Hu - Cell Calcium, 2018 - Elsevier
Calcium release-activated calcium (CRAC) channels are unique among ion channels that
are activated in response to depletion of intracellular calcium stores and are highly …
are activated in response to depletion of intracellular calcium stores and are highly …
[HTML][HTML] The T-type calcium channel CaV3. 2 regulates bladder afferent responses to mechanical stimuli
The bladder wall is innervated by a complex network of afferent nerves that detect bladder
stretch during filling. Sensory signals, generated in response to distension, are relayed to …
stretch during filling. Sensory signals, generated in response to distension, are relayed to …
Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain
Objectives Knee OA is a leading global cause of morbidity. This study investigates the
effects of knee SF from patients with OA on the activity of dorsal root ganglion sensory …
effects of knee SF from patients with OA on the activity of dorsal root ganglion sensory …
1, 4-Dihydropyridine derivatives with T-type calcium channel blocking activity attenuate inflammatory and neuropathic pain
We have recently identified a class of dihydropyridine (DHP) analogues with 30-fold
selectivity for T-type over L-type calcium channels that could be attributed to a modification …
selectivity for T-type over L-type calcium channels that could be attributed to a modification …
Opioid receptor regulation of neuronal voltage-gated calcium channels
N Weiss, GW Zamponi - Cellular and Molecular Neurobiology, 2021 - Springer
Neuronal voltage-gated calcium channels play a pivotal role in the conversion of electrical
signals into calcium entry into nerve endings that is required for the release of …
signals into calcium entry into nerve endings that is required for the release of …
Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: possible aid in chemotherapy induced neuropathy
Background One of the most discomfortable dose-limiting adverse reactions of effective
drugs for the treatment of solid tumors is a peripheral neuropathy which is the main reason …
drugs for the treatment of solid tumors is a peripheral neuropathy which is the main reason …
[HTML][HTML] Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination
Adhesion-type GPCRs (aGPCRs) participate in a vast range of physiological processes.
Their frequent association with mechanosensitive functions suggests that processing of …
Their frequent association with mechanosensitive functions suggests that processing of …
Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV1.7 and hCaV3 voltage‐gated channels
Venom‐derived peptides targeting ion channels involved in pain are regarded as a
promising alternative to current, and often ineffective, chronic pain treatments. Many peptide …
promising alternative to current, and often ineffective, chronic pain treatments. Many peptide …
Cancer–nerve interplay in cancer progression and cancer-induced bone pain
T Yoneda, M Hiasa, T Okui, K Hata - Journal of Bone and Mineral …, 2023 - Springer
Introduction Cancer-induced bone pain (CIBP) is one of the most common and debilitating
complications associated with bone metastasis. Although our understanding of the precise …
complications associated with bone metastasis. Although our understanding of the precise …
Proteome-based systems biology in chronic pain
Chronic pain represents a major medical challenge in the 21 st century. Enormous efforts
have been invested towards deciphering the complexity of chronic pain from different angles …
have been invested towards deciphering the complexity of chronic pain from different angles …