Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

One week after fertilization, human embryos implant into the uterus. This event requires the
embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo …

Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …

Gastrulation is the fundamental process in all multicellular animals through which the basic
body plan is first laid down,,–. It is pivotal in generating cellular diversity coordinated with …

Limited access to embryos has hampered the study of human embryogenesis and disorders
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …

Human pluripotent and trophoblast stem cells have been essential alternatives to
blastocysts for understanding early human development 1, 2, 3, 4. However, these simple …

Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …

Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …