Antioxidant therapies in traumatic brain injury

V Di Pietro, KM Yakoub, G Caruso, G Lazzarino… - Antioxidants, 2020 - mdpi.com
Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly
heterogeneous pathology, characterized by high mortality and disability rates. TBI is an …

Flavonoids as a natural enhancer of neuroplasticity—An overview of the mechanism of neurorestorative action

N Cichon, J Saluk-Bijak, L Gorniak, L Przyslo, M Bijak - Antioxidants, 2020 - mdpi.com
Neuroplasticity is a complex physiological process occurring in the brain for its entire life.
However, it is of particular importance in the case of central nervous system (CNS) …

[HTML][HTML] Regulatory mechanism of icariin in cardiovascular and neurological diseases

Y Wang, C Shang, Y Zhang, L Xin, L Jiao… - Biomedicine & …, 2023 - Elsevier
Cardiovascular diseases (CVDs) and neurological diseases are widespread diseases with
substantial rates of morbidity and mortality around the world. For the past few years, the …

(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice

D Lecca, M Bader, D Tweedie, AF Hoffman… - Neurobiology of …, 2019 - Elsevier
Mild traumatic brain injury (mTBI) is a risk factor for neurodegenerative disorders, such as
Alzheimer's disease (AD) and Parkinson's disease (PD). TBI-derived neuropathologies are …

Icariin promotes survival, proliferation, and differentiation of neural stem cells in vitro and in a rat model of Alzheimer's disease

D Ma, L Zhao, L Zhang, Y Li, L Zhang… - Stem cells …, 2021 - Wiley Online Library
Alzheimer's disease (AD) involves the degeneration of cholinergic neurons in the basal
forebrain. Neural stem cell (NSC) transplantation has emerged as a promising therapeutic …

[HTML][HTML] Folicitin abrogates scopolamine induced oxidative stress, hyperlipidemia mediated neuronal synapse and memory dysfunction in mice

S Gul, S Attaullah, MH Alsugoor, S Bawazeer, SA Shah… - Heliyon, 2023 - ncbi.nlm.nih.gov
No effective drug treatment is available for Alzheimer disease, thus the need arise to
develop efficient drugs for its treatment. Natural products have pronounced capability in …

[HTML][HTML] Novel synthetic and natural therapies for traumatic brain injury

D Battaglini, D Siwicka-Gieroba… - Current …, 2021 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is a major cause of disability and death worldwide. The initial
mechanical insult results in tissue and vascular disruption with hemorrhages and cellular …

The pros and cons of motor, memory, and emotion-related behavioral tests in the mouse traumatic brain injury model

R Zhang, J Wang, L Huang, TJ Wang… - Neurological …, 2022 - Taylor & Francis
Traumatic brain injury (TBI) is a medical emergency with high morbidity and mortality. Motor,
memory, and emotion-related deficits are common symptoms following TBI, yet treatment is …

Cardioprotective effect of icariin against myocardial fibrosis and its molecular mechanism in diabetic cardiomyopathy based on network pharmacology: Role of ICA in …

L Zhang, S Wang, Y Li, Y Wang, C Dong, H Xu - Phytomedicine, 2021 - Elsevier
Background Diabetic cardiomyopathy (DCM) is one of the most severe symptoms of
diabetes. It continues to be a major clinical problem, but our knowledge of its molecular …

Intradermal Injection of Icariin-HP-β-cyclodextrin improved traumatic brain injury via the trigeminal epineurium-brain dura pathway

W Yang, YH Han, HC Wang, CT Lu, XC Yu… - Journal of Drug …, 2022 - Taylor & Francis
The lower bioavailability after oral administration limited icariin applications in central
nervous system. Icariin/HP-β-cyclodextrin (HP-β-CD) inclusion complex was prepared for …