[HTML][HTML] Sex and gender driven modifiers of Alzheimer's: the role for estrogenic control across age, race, medical, and lifestyle risks

A Rahman, H Jackson, H Hristov… - Frontiers in aging …, 2019 - frontiersin.org
Research indicates that after advanced age, the major risk factor for late-onset Alzheimer's
disease is female sex. Out of every three AD patients, two are females with postmenopausal …

Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015 - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study

RH Pietrzak, YY Lim, A Neumeister, D Ames… - JAMA …, 2015 - jamanetwork.com
Importance Alzheimer disease (AD) is now known to have a long preclinical phase in which
pathophysiologic processes develop many years, even decades, before the onset of clinical …

Anxiety and Alzheimer's disease: Behavioral analysis and neural basis in rodent models of Alzheimer's-related neuropathology

NS Pentkowski, KK Rogge-Obando… - Neuroscience & …, 2021 - Elsevier
Alzheimer's disease (AD) pathology is commonly associated with cognitive decline but is
also composed of neuropsychiatric symptoms including psychological distress and …

Metabolic and non-cognitive manifestations of Alzheimer's disease: the hypothalamus as both culprit and target of pathology

M Ishii, C Iadecola - Cell metabolism, 2015 - cell.com
Alzheimer's disease (AD) is increasingly recognized as a complex neurodegenerative
disease beginning decades prior to the cognitive decline. While cognitive deficits remain the …

Revenge of the “sit” II: does lifestyle impact neuronal and cognitive health through distinct mechanisms associated with sedentary behavior and physical activity?

MW Voss, LJ Carr, R Clark, T Weng - Mental Health and Physical Activity, 2014 - Elsevier
It is generally understood that regular moderate to vigorous physical activity (MVPA)
promotes good health from head to toe. Evidence also supports the notion that too much …

Does music therapy improve anxiety and depression in alzheimer's patients?

JE De la Rubia Ortí, MP García-Pardo… - The Journal of …, 2018 - liebertpub.com
Objective: To evaluate the effectiveness of the implementation of a short protocol of music
therapy as a tool to reduce stress and improve the emotional state in patients with mild …

Central role of glucocorticoid receptors in Alzheimer's disease and depression

G Canet, N Chevallier, C Zussy, C Desrumaux… - Frontiers in …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the principal neurodegenerative pathology in the world
displaying negative impacts on both the health and social ability of patients and inducing …

Is AD a stress-related disorder? Focus on the HPA axis and its promising therapeutic targets

G Canet, C Hernandez, C Zussy… - Frontiers in aging …, 2019 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has important
health and economic impacts in the elderly. Despite a better understanding of the molecular …

Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease

B Mosaferi, Y Jand, AA Salari - Scientific Reports, 2021 - nature.com
The gut-microbiota–brain axis plays an important role in stress-related disorders, and
dysfunction of this complex bidirectional system is associated with Alzheimer's disease. This …