[HTML][HTML] YdfD, a Lysis Protein of the Qin Prophage, Is a Specific Inhibitor of the IspG-Catalyzed Step in the MEP Pathway of Escherichia coli
Z Lu, B Wang, Z Qiu, R Zhang, J Zheng… - International Journal of …, 2022 - mdpi.com
Bacterial cryptic prophage (defective prophage) genes are known to drastically influence
host physiology, such as causing cell growth arrest or lysis, upon expression. Many phages …
host physiology, such as causing cell growth arrest or lysis, upon expression. Many phages …
Medicinal use of lincosamides and microbial resistance to them
T Rezanka, J Spizek, K Sigler - Anti-Infective Agents in …, 2007 - ingentaconnect.com
Lincomycin and its derivatives are antibiotics exhibiting biological activity against bacteria,
especially Grampositive ones, and also protozoans. Lincomycin and its semi-synthetic …
especially Grampositive ones, and also protozoans. Lincomycin and its semi-synthetic …
[HTML][HTML] Experimental Genetics of Plasmodium berghei NFU in the Apicoplast Iron-Sulfur Cluster Biogenesis Pathway
JM Haussig, K Matuschewski, TWA Kooij - PloS one, 2013 - journals.plos.org
Eukaryotic pathogens of the phylum Apicomplexa contain a non-photosynthetic plastid,
termed apicoplast. Within this organelle distinct iron-sulfur [Fe-S] cluster proteins are likely …
termed apicoplast. Within this organelle distinct iron-sulfur [Fe-S] cluster proteins are likely …
Synthesis and inhibition studies towards the discovery of benzodiazepines as potential antimalarial compounds
The target-based discovery of therapeutics against apicoplast, an all-important organelle is
an overriding perspective. MEP pathway, an accredited drug target provides an insight into …
an overriding perspective. MEP pathway, an accredited drug target provides an insight into …
[HTML][HTML] Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”
MS Felín, K Wang, A Moreira, A Grose, K Leahy… - Current Pediatrics …, 2022 - Springer
Abstract Purpose of Review Review international efforts to build a global public health
initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and …
initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and …
Drugs and drug leads based on natural products for treatment and prophylaxis of malaria
SB Christensen - Evidence-Based Validation of Herbal Medicine, 2015 - Elsevier
In the first part important natural products registered as or transformed into registered
antimalarial drugs are reviewed together with their mechanisms of action. The mentioned …
antimalarial drugs are reviewed together with their mechanisms of action. The mentioned …
FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and …
J Wiesner, C Ziemann, M Hintz, A Reichenberg… - Virulence, 2016 - Taylor & Francis
ABSTRACT FR-900098 is an inhibitor of 1-deoxy-d-xylulose-5-phosphate (DXP)
reductoisomerase, the second enzyme in the non-mevalonate isoprenoid biosynthesis …
reductoisomerase, the second enzyme in the non-mevalonate isoprenoid biosynthesis …
Biosynthesis of isoprenoids – studies on the mechanism of 2C‐methyl‐d‐erythritol‐4‐phosphate synthase
S Lauw, V Illarionova, A Bacher, F Rohdich… - The FEBS …, 2008 - Wiley Online Library
2C‐Methyl‐d‐erythritol‐4‐phosphate synthase, encoded by the ispC gene (also designated
dxr), catalyzes the first committed step in the nonmevalonate isoprenoid biosynthetic …
dxr), catalyzes the first committed step in the nonmevalonate isoprenoid biosynthetic …
Interaction of apicoplast-encoded elongation factor (EF) EF-Tu with nuclear-encoded EF-Ts mediates translation in the Plasmodium falciparum plastid
S Biswas, EE Lim, A Gupta, U Saqib, SS Mir… - International journal for …, 2011 - Elsevier
Protein translation in the plastid (apicoplast) of Plasmodium spp. is of immense interest as a
target for potential anti-malarial drugs. However, the molecular data on apicoplast …
target for potential anti-malarial drugs. However, the molecular data on apicoplast …
Antimalarial drugs and their useful therapeutic lives: rational drug design lessons from pleiotropic action of quinolines and artemisinins
FW Muregi - Current drug discovery technologies, 2010 - ingentaconnect.com
Efforts to develop an effective malarial vaccine are yet to be successful and thus
chemotherapy remains the mainstay of malaria control strategy. Unfortunately, Plasmodium …
chemotherapy remains the mainstay of malaria control strategy. Unfortunately, Plasmodium …