Bacterial cryptic prophage (defective prophage) genes are known to drastically influence
host physiology, such as causing cell growth arrest or lysis, upon expression. Many phages …

Lincomycin and its derivatives are antibiotics exhibiting biological activity against bacteria,
especially Grampositive ones, and also protozoans. Lincomycin and its semi-synthetic …

Eukaryotic pathogens of the phylum Apicomplexa contain a non-photosynthetic plastid,
termed apicoplast. Within this organelle distinct iron-sulfur [Fe-S] cluster proteins are likely …

The target-based discovery of therapeutics against apicoplast, an all-important organelle is
an overriding perspective. MEP pathway, an accredited drug target provides an insight into …

Abstract Purpose of Review Review international efforts to build a global public health
initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and …

In the first part important natural products registered as or transformed into registered
antimalarial drugs are reviewed together with their mechanisms of action. The mentioned …

ABSTRACT FR-900098 is an inhibitor of 1-deoxy-d-xylulose-5-phosphate (DXP)
reductoisomerase, the second enzyme in the non-mevalonate isoprenoid biosynthesis …

2C‐Methyl‐d‐erythritol‐4‐phosphate synthase, encoded by the ispC gene (also designated
dxr), catalyzes the first committed step in the nonmevalonate isoprenoid biosynthetic …

Protein translation in the plastid (apicoplast) of Plasmodium spp. is of immense interest as a
target for potential anti-malarial drugs. However, the molecular data on apicoplast …

Efforts to develop an effective malarial vaccine are yet to be successful and thus
chemotherapy remains the mainstay of malaria control strategy. Unfortunately, Plasmodium …