Management of severe acute respiratory distress syndrome: a primer

JC Grotberg, D Reynolds, BD Kraft - Critical Care, 2023 - Springer
This narrative review explores the physiology and evidence-based management of patients
with severe acute respiratory distress syndrome (ARDS) and refractory hypoxemia, with a …

Current and evolving standards of care for patients with ARDS

M Menk, E Estenssoro, SK Sahetya, AS Neto… - Intensive care …, 2020 - Springer
Care for patients with acute respiratory distress syndrome (ARDS) has changed
considerably over the 50 years since its original description. Indeed, standards of care …

Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance

EC Goligher, ELV Costa, CJ Yarnell… - American journal of …, 2021 - atsjournals.org
Rationale: If the risk of ventilator-induced lung injury in acute respiratory distress syndrome
(ARDS) is causally determined by driving pressure rather than by Vt, then the effect of …

Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study

M Urner, AG Barnett, GL Bassi, D Brodie, HJ Dalton… - bmj, 2022 - bmj.com
Objective To estimate the effect of extracorporeal membrane oxygenation (ECMO)
compared with conventional mechanical ventilation on outcomes of patients with covid-19 …

Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study

L Chen, DL Grieco, F Beloncle, GQ Chen… - Intensive Care …, 2022 - Springer
Purpose In acute respiratory distress syndrome (ARDS), physiological parameters
associated with outcome may help defining targets for mechanical ventilation. This study …

Effect of mechanical power on mortality in invasively ventilated ICU patients without the acute respiratory distress syndrome: An analysis of three randomised clinical …

DMP Van Meenen, AG Algera… - European Journal of …, 2023 - journals.lww.com
BACKGROUND The mechanical power of ventilation (MP) has an association with outcome
in invasively ventilated patients with the acute respiratory distress syndrome (ARDS) …

Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure: insights from the PRoVENT-COVID study

MTU Schuijt, MJ Schultz, F Paulus, A Serpa Neto - Critical care, 2021 - Springer
Background The intensity of ventilation, reflected by driving pressure (ΔP) and mechanical
power (MP), has an association with outcome in invasively ventilated patients with or without …

Precision medicine and heterogeneity of treatment effect in therapies for ARDS

YA Khan, E Fan, ND Ferguson - Chest, 2021 - Elsevier
ARDS is a clinically heterogeneous syndrome, rather than a distinct disease. This
heterogeneity at least partially explains the difficulty in studying treatments for these patients …

Intra-operative ventilator mechanical power as a predictor of postoperative pulmonary complications in surgical patients: a secondary analysis of a randomised clinical …

D Karalapillai, L Weinberg, P Peyton… - European Journal of …, 2022 - journals.lww.com
BACKGROUND Studies in critically ill patients suggest a relationship between mechanical
power (an index of the energy delivered by the ventilator, which includes driving pressure …

Ultra-low tidal volume ventilation for COVID-19-related ARDS in France (VT4COVID): a multicentre, open-label, parallel-group, randomised trial

JC Richard, N Terzi, H Yonis, F Chorfa… - The Lancet …, 2023 - thelancet.com
Background COVID-19-related acute respiratory distress syndrome (ARDS) is associated
with a high mortality rate and longer mechanical ventilation. We aimed to assess the …