Natural products as modulators of Nrf2 signaling pathway in neuroprotection

I Moratilla-Rivera, M Sánchez… - International Journal of …, 2023 - mdpi.com
Neurodegenerative diseases (NDs) affect the West due to the increase in life expectancy.
Nervous cells accumulate oxidative damage, which is one of the factors that triggers and …

[HTML][HTML] Nrf2: An all-rounder in depression

C Zuo, H Cao, Y Song, Z Gu, Y Huang, Y Yang, J Miao… - Redox biology, 2022 - Elsevier
The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …

[HTML][HTML] Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression

MA Tayab, MN Islam, KAA Chowdhury… - Biomedicine & …, 2022 - Elsevier
Depression is the most prevalent and debilitating mental disorder that affects a substantial
number of people globally, hindering all aspects of their lives and leading to a high number …

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

S Chen, Y Tang, Y Gao, K Nie, H Wang, H Su… - Frontiers in …, 2022 - frontiersin.org
Depression is a global health problem with growing prevalence rates and serious impacts
on the daily life of patients. However, the side effects of currently used antidepressants …

Anti-Inflammatory, Antioxidant, and Neuroprotective Effects of Polyphenols—Polyphenols as an Element of Diet Therapy in Depressive Disorders

A Winiarska-Mieczan, M Kwiecień… - International Journal of …, 2023 - mdpi.com
Depressive disorders can affect up to 350 million people worldwide, and in developed
countries, the percentage of patients with depressive disorders may be as high as 10 …

Flavonols in action: Targeting oxidative stress and neuroinflammation in major depressive disorder

M Jazvinšćak Jembrek, N Oršolić, D Karlović… - International journal of …, 2023 - mdpi.com
Major depressive disorder is one of the most common mental illnesses that highly impairs
quality of life. Pharmacological interventions are mainly focused on altered monoamine …

Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action

P Bellavite - Antioxidants, 2023 - mdpi.com
Neurological and neurodegenerative diseases, particularly those related to aging, are on
the rise, but drug therapies are rarely curative. Functional disorders and the organic …

Quercetin alleviates the progression of breast cancer‐related depression via inhibiting the Pyroptosis and promoting the immune response

Q Zhu, L Yang, H Yang, Y Han… - Mediators of …, 2022 - Wiley Online Library
Background. Breast cancer‐related depression (BCRD) seriously inhibits the life quality of
patients with breast cancer. The Xiaoyao Kangai Jieyu Formula is known to inhibit the …

The potential of flavonoids and flavonoid metabolites in the treatment of neurodegenerative pathology in disorders of cognitive decline

J Melrose - Antioxidants, 2023 - mdpi.com
Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-
inflammatory, antiviral, and antibacterial cell protective profiles. They have received …

The Nrf2 pathway in depressive disorders: a systematic review of animal and human studies

G Sani, S Margoni, A Brugnami, OM Ferrara… - Antioxidants, 2023 - mdpi.com
There is increasing interest in the involvement of antioxidative systems in protecting from
depression. Among these, Nrf2 occupies a central place. We aimed to review the role of Nrf2 …