ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis

TM Bui, HL Wiesolek, R Sumagin - Journal of Leucocyte Biology, 2020 - academic.oup.com
ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for
regulating leukocyte recruitment from circulation to sites of inflammation. However, in …

DAMPs and NETs in sepsis

NL Denning, M Aziz, SD Gurien, P Wang - Frontiers in immunology, 2019 - frontiersin.org
Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …

Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain

J Nong, PM Glassman, JW Myerson… - ACS …, 2023 - ACS Publications
Ex vivo-loaded white blood cells (WBC) can transfer cargo to pathological foci in the central
nervous system (CNS). Here we tested affinity ligand driven in vivo loading of WBC in order …

ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia

A Woodfin, M Beyrau, MB Voisin, B Ma… - Blood, The Journal …, 2016 - ashpublications.org
Abstract Intracellular adhesion molecule-1 (ICAM-1) is a transmembrane glycoprotein
expressed on the cell surface of numerous cell types such as endothelial and epithelial …

Normal pregnancy is associated with peripheral leukocyte activation

P Luppi, C Haluszczak, M Trucco… - American Journal of …, 2002 - Wiley Online Library
PROBLEM: Normal pregnancy has been described as both a pro‐inflammatory condition
and a T helper (Th) 2‐dominated state. Deviations in the percentage of different …

Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase

B Zingarelli, C Szabo, AL Salzman - Gut, 1999 - gut.bmj.com
BACKGROUND Oxidative and nitrosative stress have been implicated in the pathogenesis
of inflammatory bowel diseases. AIMS To study the role of nitric oxide (NO) derived from …

Pancreatic ductal adenocarcinoma: a review of immunologic aspects

MB Wachsmann, LM Pop… - Journal of Investigative …, 2012 - journals.sagepub.com
With the continued failures of both early diagnosis and treatment options for pancreatic
cancer, it is now time to comprehensively evaluate the role of the immune system on the …

Regulation of ICAM-1 in human neutrophils

M Vignarajah, AJT Wood, E Nelmes… - Journal of Leukocyte …, 2024 - academic.oup.com
Intercellular cell adhesion molecule 1 (ICAM-1) is a cell surface glycoprotein with a vital role
in the immune response to pathogens. The expression pattern of ICAM-1 is wide ranging …

Glucose-free dialysis solutions: inductors of inflammation or preservers of peritoneal membrane?

TA Martikainen, AM Teppo… - Peritoneal Dialysis …, 2005 - journals.sagepub.com
Objectives Glucose and other bioincompatible factors of conventional peritoneal dialysis
solutions may damage the peritoneal membrane. The aim of our study was to investigate …

Monocyte cell adhesion induced by a human aminoacyl-tRNA synthetase-associated factor, p43: identification of the related adhesion molecules and signal pathways

H Park, SG Park, JW Lee, T Kim, G Kim… - Journal of leukocyte …, 2002 - academic.oup.com
An aminoacyl-tRNA synthetase-associated factor, p43, was recently shown to be secreted to
induce a proinflammatory response. Because a proinflammatory response involves the cell …