Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and
has a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC …

DNA methylation, an epigenetic modification, regulates gene transcription and maintains
genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at …

Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a
promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic …

Peripheral T-cell lymphomas (PTCLs) are uniquely vulnerable to epigenetic modifiers. We
demonstrated in vitro synergism between histone deacetylase inhibitors and DNA …

The emergence of nanotechnology applied to medicine has revolutionized the treatment of
human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

The detection of tumor-derived cell-free DNA in plasma is one of the most promising
directions in cancer diagnosis. The major challenge in such an approach is how to identify …

Fumarate hydratase (FH) is an enzyme of the Tricarboxylic Acid (TCA) cycle whose
mutations lead to hereditary and sporadic forms of cancer. Although more than twenty years …

Life expectancy has grown dramatically in modern times. This increase, however, is not
accompanied by the same increase in healthspan. Efforts to extend healthspan through …